Results 111 to 120 of about 15,495,313 (386)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Global Ecology and Conservation, 2015 Synergistic effect refers to simultaneous actions of separate factors which have a greater total effect than the sum of the individual factor effects. However, there has been a limited knowledge on how synergistic effects occur and individual roles of ...
Shuihua Chen +7 more
doaj +1 more source
Life History of \u3ci\u3eNeoplea Striola\u3c/i\u3e (Hemiptera: Pleidae) [PDF]
, 2017 The life history of Neoplea striola was studied in southern Illinois during 1983-1985. This apparently univoltine species overwintered as adults and became active in early March.
McPherson, J. E
core +2 more sources
Natural History, Quality of Life, and Outcome in Cardiac Transthyretin Amyloidosis.
Circulation, 2019 BACKGROUND Transthyretin amyloidosis cardiomyopathy (ATTR-CM) is an increasingly recognized cause of heart failure in older individuals. We sought to characterize the natural history of ATTR-CM and compare outcomes and quality of life among patients with
T. Lane +24 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
Local biodiversity is higher inside than outside terrestrial protected areas worldwide
Nature Communications, 2016 Protected areas are thought essential for biodiversity conservation, but few studies confirm that protection benefits species. Here, Gray and Hill et al. analyse a global, taxonomically broad database to show that local species richness and abundance are
Claudia L. Gray +9 more
doaj +1 more source
Oyster shells as history books [PDF]
, 2003 [FIRST PARAGRAPH] A collaborative project was established in 2002 that has brought together geochemistry and archaeology in order to investigate environmental change and the harvesting strategies of ancient peoples.
Milner, N., Surge, D.
core
Life history and ecological genetics of the colonial ascidian Botryllus schlosseri [PDF]
, 2015 The colonial ascidian Botryllus schlosseri is a cosmopolitan, marine filter feeder, introduced as a laboratory research organism in the 1950s. Currently, it is widely used in many laboratories to investigate a variety of biological questions.
Ballarin, Loriano +7 more
core +1 more source