Results 111 to 120 of about 15,880,890 (357)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Human harvest, climate change and their synergistic effects drove the Chinese Crested Tern to the brink of extinction

Global Ecology and Conservation, 2015
Synergistic effect refers to simultaneous actions of separate factors which have a greater total effect than the sum of the individual factor effects. However, there has been a limited knowledge on how synergistic effects occur and individual roles of ...
Shuihua Chen, Zhongyong Fan, Daniel D. Roby, Yiwei Lu, Cangsong Chen, Qin Huang, Lijing Cheng, Jiang Zhu   +7 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Two new species of Pelagodes Holloway, 1996 from Eastern New Guinea (Lepidoptera: Geometridae, Geometrinae, Thalassodini)

SHILAP
Two new species of the Indo-Australian genus Pelagodes Holloway, 1996 are described as new. Pelagodes sebastiani Lindt, Lennuk & Viidalepp, sp. nov. resembles Pelagodes rana Holloway, 1996 in the shape of its frog-leglike appendages on the male eighth ...
Aare Lindt, Lennart Lennuk, Jaan Viidalepp   +2 more
doaj   +1 more source

Local biodiversity is higher inside than outside terrestrial protected areas worldwide

Nature Communications, 2016
Protected areas are thought essential for biodiversity conservation, but few studies confirm that protection benefits species. Here, Gray and Hill et al. analyse a global, taxonomically broad database to show that local species richness and abundance are
Claudia L. Gray, Samantha L. L. Hill, Tim Newbold, Lawrence N. Hudson, Luca Börger, Sara Contu, Andrew J. Hoskins, Simon Ferrier, Andy Purvis, Jörn P. W. Scharlemann   +9 more
doaj   +1 more source

Anchonini in Africa: New Species and Genus Confirming a Transatlantic Distribution (Coleoptera: Curculionidae: Molytinae)

Diversity, 2018
The Anchonini known from Africa are reviewed. The monotypic genus Aethiopacorep is redescribed. The new West African genus Titilayo gen. nov. is described, with seven new species: four from São Tomé, T. perrinae sp. nov., T. saotomense sp.
Joana P. Cristóvão, Christopher H. C. Lyal   +1 more
doaj   +1 more source

Village History 1 [PDF]

, 2010
Zhangs skyong tells village history concerning a demon which almost destroyed the village.The fifty one audio and nine video files in this collection include: villages’ life stories, circle-dancing songs and performance, local history, folk tales, and ...
G.yu lha
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Two new species of Rhodochlora Warren, 1894 of the Neotropics (Lepidoptera: Geometridae, Geometrinae)

SHILAP
Rhodochlora Warren, 1894 is a Neotropical genus of the largest and most attractive species of their kind. This article aims to characterize two additional species.
Jaan Viidalepp, Lennart Lennuk, Aare Lindt   +2 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source