Results 111 to 120 of about 2,032,204 (309)

Space shuttle nonmetallic materials age life prediction [PDF]

The chemiluminescence from samples of polybutadiene, Viton, Teflon, Silicone, PL 731 Adhesive, and SP 296 Boron-Epoxy composite was measured at temperatures from 25 to 150 C. Excellent correlations were obtained between chemiluminescence and temperature.
Hassell, J. A., Mendenhall, G. D., Nathan, R. A.   +2 more
core   +1 more source

Corrosion assessment on reinforced concrete and its service life prediction [PDF]

, 2005
Deterioration of structural concrete may be caused either by chemical or physical effects. Corrosion of embedded steel is a major cause of deterioration of concrete structures at the present time.
Syed Mohamad, Syed Burhanuddin Hilmi
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

High cycle fatigue behavior study and evaluation for GH3536 alloy fabricated by laser powder bed fusion

Cailiao gongcheng
Additive manufacturing of nickel-based superalloys holds significant promise for applications in aero-engines and gas turbines. Evaluating the mechanical properties of these materials is crucial for facilitating their use in load-bearing components. This
ZHANG Jiaming, JIAO Zehui, ZHANG Li, HUANG Shuai, WU Liangliang, HE Yuhuai, LI Longjian, KANG Huijun   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Review on Rail Damage Detection Technologies for High-Speed Trains

Applied Sciences
From the point of view of the intelligent operation and maintenance of high-speed train tracks, this paper examines the research status of high-speed train rail damage detection technology in the field of high-speed train track operation and maintenance ...
Yu Wang, Bingrong Miao, Ying Zhang, Zhong Huang, Songyuan Xu   +4 more
doaj   +1 more source

Evaluation of structural analysis methods for life prediction [PDF]

The utility of advanced constitutive models and structural analysis methods are evaluated for predicting the cyclic life of an air-cooled turbine blade for a gas turbine aircraft engine.
Halford, G. R., Kaufman, A., Saltsman, J. F., Tong, M.   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A small-sample multiaxial fatigue life prediction method for titanium alloys based on a parameter fusion model

Materials Research Express
A physics data fusion driven strategy for estimating the multiaxial fatigue life of titanium alloys is proposed. Using TC4 titanium alloy as the research subject, multiaxial fatigue experiments are performed and a physical framework is created by ...
Jiao Li, Qi Li, Feng Wang, Mingshan Lou, Liuxiangzi Yang   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source