Results 131 to 140 of about 2,032,204 (309)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Life extending control: An interdisciplinary engineering thrust [PDF]
The concept of Life Extending Control (LEC) is introduced. Possible extensions to the cyclic damage prediction approach are presented based on the identification of a model from elementary forms. Several candidate elementary forms are presented.
Lorenzo, Carl F., Merrill, Walter C.
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Life prediction modeling based on cyclic damage accumulation [PDF]
A high temperature, low cycle fatigue life prediction method was developed. This method, Cyclic Damage Accumulation (CDA), was developed for use in predicting the crack initiation lifetime of gas turbine engine materials, where initiation was defined as ...
Nelson, Richard S.
core +1 more source
Life prediction of materials exposed to monotonic and cyclic loading: A technology survey and bibliography [PDF]
, 1975 Announced survey directs attention toward low cycle fatigue and thermal fatigue experienced at elevated temperatures equivalent to those found in hot end of gas turbine engine.
Carpenter, J. L., Jr. +3 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Bending fatigue life prediction of honeycomb sandwich structures
Hangkong gongcheng jinzhanComposite sandwich panels possess the characterizations of lightweight and high load-bearing capacity. They also face diverse failure modes，and an in-depth study of their mechanical performance and failure mechanisms is essential to ensure structural ...
DONG Fan +4 more
doaj +1 more source
Prediction of service life of polymeric sealant compositions for fuel tanks in aerospace structures from measurements of viscoelastic properties Annual report [PDF]
Prediction of service life of polymeric sealers for fuel tanks from viscoelastic ...
Boni, K. A. +3 more
core +1 more source