Results 121 to 130 of about 679,610 (316)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Multi-period credit default prediction with time-varying covariates [PDF]
In credit default prediction models, the need to deal with time-varying covariates often arises. For instance, in the context of corporate default prediction a typical approach is to estimate a hazard model by regressing the hazard rate on time-varying ...
Orth, Walter
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Fretting fatigue life prediction using the extended finite element method [PDF]
, 2010 In this work, fretting fatigue tests available in the literature are modeled using the extended finite element method (XFEM). The aim is to numerically evaluate the stress intensity factors (SIFs) for cracks of different lengths emanating at the end of ...
Fuenmayor, F.J. +5 more
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Materials Research ExpressA physics data fusion driven strategy for estimating the multiaxial fatigue life of titanium alloys is proposed. Using TC4 titanium alloy as the research subject, multiaxial fatigue experiments are performed and a physical framework is created by ...
Jiao Li +4 more
doaj +1 more source
Review on Rail Damage Detection Technologies for High-Speed Trains
Applied SciencesFrom the point of view of the intelligent operation and maintenance of high-speed train tracks, this paper examines the research status of high-speed train rail damage detection technology in the field of high-speed train track operation and maintenance ...
Yu Wang +4 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Reliability-based life prediction of aging concrete bridge decks
, 2000 This paper presents a probabilistic approach to life prediction of concrete highway bridge decks based on Bogdanoff''s cumulative damage model. The condition of the deck is discretized into a finite set of damage states including no damage, onset of ...
Lounis, Z.
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2007 A means to predict remaining strength and life of composite components in harsh environments and under complex time-varying loadings can help to optimize designs and cut costs.
Prediction Of Stress-Rupture
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