Results 121 to 130 of about 8,033,101 (355)
Life science payloads planning study integration facility survey results [PDF]
The integration facility survey effort described is structured to examine the facility resources needed to conduct life science payload (LSP) integration checkout activities at NASA-JSC.
Brown, N. E. +2 more
core +1 more source
Ripping yarns: Science in Asia [PDF]
, 2010 The article explores the life and works of botanist Joseph Rock, historian Joseph Needham, and physicist J. C. Bose. Rock's expeditions and personality have become an enduring part of China's history which shows the notion that scientists participate in ...
Barker, Miles
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
SLAS Technology: Translating Life Sciences Innovation [PDF]
, 2017 Edward Kai‐Hua Chow
openalex +1 more source
Biophotonics: a marriage of sciences [PDF]
, 2002 Biophotonics denotes a combination of biology and photonics, with photonics being the science and technology of generation, manipulation, and detection of photons, quantum units of light.
Girkin, J.M.
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Life Science Payloads Planning Study Integration Facility Survey: Executive Summary [PDF]
Analyses of proposed life science shuttle era payload operations are discussed. A summary of results from a survey conducted to: (1) examine facility and equipment resources needed for life science payload integration, checkout, test and mission support ...
Brown, N. E., Wells, G. W.
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Probability, propensity and probabilities of propensities (and of probabilities)
, 2016 The process of doing Science in condition of uncertainty is illustrated with a toy experiment in which the inferential and the forecasting aspects are both present.
D'Agostini, Giulio
core +1 more source