Results 91 to 100 of about 17,023,679 (280)

From Systems Biology to Systems Biomedicine

, 2012
peer reviewedSystems Biology is about combining theory, technology, and targeted experiments in a way that drives not only data accumulation but knowledge as well.
Paul MA Antony, BALLING, Rudi, Rudi Balling, Nikos Vlassis, ANTONY, Paul, VLASSIS, Nikos   +5 more
core   +1 more source

Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin

Nature Communications
Hemorrhagic toxin (TcsH) is a major virulence factor produced by Paeniclostridium sordellii, which is a non-negligible threat to women undergoing childbirth or abortions.
Ruoyu Zhou, Liuqing He, Jiahao Zhang, Xiaofeng Zhang, Yanyan Li, Xiechao Zhan, Liang Tao   +6 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

UNICORE – a middleware for Life Sciences grids

, 2009
The Handbook of Research on Computational Grid Technologies for Life Sciences, Biomedicine, and Healthcare brings together state-of-the art methodologies and developments of grid technologies applied in different fields of life sciences. This Handbook of
Baldridge, K K, Rasch, K, Sild, S, Williams, N, Bala, P, Benfenati, E, Schöne, R, Miroslaw, L, Casalegno, M, Ostropytskyy, V, Maran, U   +10 more
core   +1 more source

A previously undescribed archaeal virus suppresses host immunity

EMBO Reports
Extremophilic archaea can have chronic viral infections that are well-tolerated by the hosts and may potentially protect against more lethal infections.
Israela Turgeman-Grott, Noam Golan, Uri Neri, Doron Naki, Neta Altman-Price, Kim Eizenshtein, Deepak K Choudhary, Rachel Levy, Sharon Navok, Lee Cohen, Yarden Shalev, Himani Singla, Leah Reshef, Uri Gophna   +13 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Maintaining mitochondrial DNA copy number mitigates ROS-induced oocyte decline and female reproductive aging

Communications Biology
Oocytes play a crucial role in transmitting maternal mitochondrial DNA (mtDNA), essential for the continuation of species. However, the effects of mitochondrial reactive oxygen species (ROS) on mammalian oocyte maturation and mtDNA maintenance remain ...
Shiyun Long, Yunchao Zheng, Xiaoling Deng, Jing Guo, Zhe Xu, Karin Scharffetter-Kochanek, Yanmei Dou, Min Jiang   +7 more
doaj   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source