Results 101 to 110 of about 17,023,679 (280)
The EMBO JournalSex determination in animals is not only determined by karyotype but can also be modulated by environmental cues like temperature via unclear transduction mechanisms. Moreover, in contrast to earlier views that sex may exclusively be determined by either
Jing Shi +5 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
DNA methylation meets lineage tracing: History, recent progress, and future directions
Quantitative BiologyLineage tracing techniques have been developed rapidly in the past decades by employing new genetic engineering tools. However, due to their invasive nature, these are difficult to apply to humans.
Ruijiang Fu +2 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Application of enhanced Raman techniques in life sciences and biomedicine [PDF]
, 2016 Current understanding of complex biological processes and structures relies entirely on available imaging and sensing techniques. As many of these investigation tools suffer from severe limitations, the need for methods which can provide new insight is growing rapidly.
openaire
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Landscapes in Flux. Book of Proceedings [PDF]
, 2015 Peer reviewed proceedings ECLAS 2015 Conference|21 to 23 September| Department of Landscape Architecture, Estonian University of Life Sciences, Tartu, EstoniaEvery scientific paper published in these Conference Proceedings was peer reviewed.
Estonian University of Life Sciences. Department of Landscape Architecture
core +1 more source
Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer
Nature CommunicationsCancer incidence escalates exponentially with advancing age; however, the underlying mechanism remains unclear. In this study, we build a chronological molecular clock at single-cell transcription level with a mammary stem cell-enriched population to ...
Huiru Bai +8 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source