Results 61 to 70 of about 498,250 (260)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effect of life skills training on self-concept of students with academic failure [PDF]

open access: yesپژوهش در نظام‌های آموزشی, 2016
The purpose of this study was to investigate the effect of life skills training on self-concept of students with academic failure. The research method was semi-experimental with pretest-posttest design with control group.
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doaj  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Teaching Cooking Skills to Young Women with Mild Intellectual Disability: The Effectiveness of Internet Websites

open access: yesCurrent Issues in Education, 2014
The purpose of this preliminary study was to evaluate the effectiveness of using streaming video websites to improve, maintain, and generalize the cooking (meal-making) skills of four young women (18-22 years old) diagnosed with intellectual disabilities.
Hanadi Hussein Alqahtani   +1 more
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Rethink education and skills in outdoor education: “on the door” approach emerging from Dolomiti-Unesco project

open access: yesFormare
The achievement of socio-political goals of ecological transition goes through the qualification of education and training systems and teacher expertise.
Chiara Urbani, Andrea Guaran
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Concept Mapping and the CO-OP Approach with Adolescents with Autism Spectrum Disorder: Exploring Participant Experiences

open access: yesOpen Journal of Occupational Therapy, 2018
Background: To explore the experiences of adolescents with ASD participating in a novel occupationally based intervention. Methods: The intervention used concept mapping in combination with the CO-OP approach with 10 adolescents with ASD in a 4 week ...
Dr. Jessie Wilson   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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