Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
A cross-sectional study on adherence to treatment and life-style modifications in hypertensive patients attending the urban health centre of a teaching hospital in Hyderabad. [PDF]
Varma P +4 more
europepmc +1 more source
Presenting a Model for Innovative Organizational Culture in the Islamic Azad University of Mazandaran Region based on Transformational Leadership Style, Professional Ethics, and Quality of Work Life [PDF]
Forough Ramazannia +2 more
openalex +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Since nurses spend most of their working time indoors, the quality of the hospital environment has a great impact on their performance and comfort. The aim of this study was to investigate the combined effects of physical factors in the workplace and ...
keivan saedpanah +4 more
doaj
Metabolic syndrome and life style factors among diabetes patients attending in a teaching hospital, Chitwan. [PDF]
Sharma K +3 more
europepmc +1 more source
Education styles in a family versus life aims and values preferred by young people [PDF]
Małgorzata Dubis
openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Risk Factors for Endometriosis: Menstrual and Life-Style Characteristics [PDF]
Kathleen G. Waller, Robert W. Shaw
openalex +1 more source

