Results 101 to 110 of about 17,240,228 (299)

Triggers for Palliative Care consultation and its modalities in non-malignant mechanically ventilated patients in the Intensive Care Unit: A prospective observational study

Clinical Epidemiology and Global Health
Aim and objectives: To determine the triggers for palliative care consultation (PCC) in non-malignant mechanically ventilated (MV) patients admitted to intensive care unit (ICU) and factors affecting modalities of palliative care (PC) delivery.
Mansi Suresh, Souvik Chaudhuri, Krithika Rao, Pratibha Todur   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Multi-centred mixed-methods PEPFAR HIV care & support public health evaluation: study protocol. [PDF]

, 2010
BACKGROUND: A public health response is essential to meet the multidimensional needs of patients and families affected by HIV disease in sub-Saharan Africa.
McCrone Paul, Irene J Higginson, Faith Mwangi-Powell, Scott Moreland, Mwangi-Powell, Faith, Peter Fayers, Fayers, Peter, Downing, Julia, Harding, Richard, Powell, Richard A., Mwangi-Powell Faith, Moreland, Scott, Simms, Victoria, Paul McCrone, Penfold, Suzanne, Higginson, Irene J.; id_orcid, Fayers Peter, Richard Harding, Victoria Simms, Curtis Siân, Julia Downing, Namisango Eve, Powell, Richard A, Penfold Suzanne, Higginson, Irene J, Simms Victoria, Higginson Irene J, Moreland Scott, Siân Curtis, Eve Namisango, Downing Julia, Suzanne Penfold, Richard A Powell, McCrone, Paul, Curtis, Siân, Powell Richard A, Harding Richard, Namisango, Eve   +37 more
core   +2 more sources

Limitação de Suporte Avançado de Vida em pacientes admitidos em unidade de terapia intensiva com cuidados paliativos integrados

Revista Brasileira de Terapia Intensiva
RESUMO Objetivo: Estimar a incidência de limitação de Suporte Avançado de Vida em pacientes graves internados em unidade de terapia intensiva com cuidados paliativos integrados.
Sandra Regina Gonzaga Mazutti, Andréia de Fátima Nascimento, Renata Rego Lins Fumis   +2 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

(LGBTQ+) Care in Later Life : A Learning Framework for Knowledge, Skills and Values for Working Affirmatively with LGBTQ+ People in Later Life [PDF]

, 2023
This learning framework for working with LGBTQ+ people in later life aims to provide a base for identifying the insights, knowledge, understanding and skills that the social care workforce need to help them work affirmatively, inclusively and effectively
Roberts, Lawrence, Hafford-Letchfield, Trish   +1 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source