Results 101 to 110 of about 1,917,089 (269)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Social networks, work and network-based resources for the management of long-term conditions: a framework and study protocol for developing self-care support [PDF]

, 2011
Background: increasing the effective targeting and promotion of self-care support for long-term conditions requires more of a focus on patient contexts and networks.
Christian Blickem, Brooks, Helen; id_orcid, Anne Kennedy, Anne Rogers, Fullwood, Catherine, Vassilev, Ivaylo, Reeves, David, Helen Brooks, David Reeves, Brooks, Helen, Joanne Protheroe, Kapadia, Dharmi, Sanders, Caroline, Dharmi Kapadia, Peter Bower, Bower, Peter, Carolyn Chew-Graham, Sanders, Caroline; id_orcid, Bower, Peter; id_orcid, Blickem, Christian, Susan Kirk, Caroline Sanders, Catherine Fullwood, Rogers, Anne, Kennedy, Anne, Richardson, Gerry, Kapadia, Dharmi; id_orcid, Protheroe, Joanne, Ivaylo Vassilev, Kirk, Susan, Chew-Graham, Carolyn, Gerry Richardson   +31 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Administering anticipatory medications in end-of-life care: A qualitative study of nursing practice in the community and in nursing homes. [PDF]

, 2014
In the United Kingdom, an approach to improving end-of-life care has been the introduction of 'just in case' or 'anticipatory' medications. Nurses are often responsible for deciding when to use anticipatory medications, but little is known about their ...
Morbey, H., Seymour, J, Morbey, Hazel, Wilson, E., Seale, Olive, Morbey, H, Seymour, Jane, Payne, Sheila, Payne, S, Payne, S., Wilson, E, Seymour, J., Brown, Jayne, Seale, C., Wilson, Eleanor, Seale, C, Brown, J, Seale, Clive, Brown, J.   +18 more
core   +1 more source

No evidence for a causal link between Helicobacter pylori infection and Irritable bowel syndrome: a Mendelian randomization study

Frontiers in Microbiology
BackgroundAlthough clinical studies have revealed a potential link between Helicobacter pylori (H. pylori) infection and irritable bowel syndrome (IBS), the causal relationship between them remains unknown.
Chenchen Wang, Chenchen Wang, Jing Zhang, Fengli Han, Dong Liu, Yuying Han   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Triggers for Palliative Care consultation and its modalities in non-malignant mechanically ventilated patients in the Intensive Care Unit: A prospective observational study

Clinical Epidemiology and Global Health
Aim and objectives: To determine the triggers for palliative care consultation (PCC) in non-malignant mechanically ventilated (MV) patients admitted to intensive care unit (ICU) and factors affecting modalities of palliative care (PC) delivery.
Mansi Suresh, Souvik Chaudhuri, Krithika Rao, Pratibha Todur   +3 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Can comprehensive specialised end-of-life care be provided at home? Lessons from a study of an innovative consultant-led community service in the UK [PDF]

, 2015
The Midhurst Macmillan Specialist Palliative Care Service (MMSPCS) is a UK, medical consultant-led, multidisciplinary team aiming to provide round-the-clock advice and care, including specialist interventions, in the home, community hospitals and care ...
Winslow, M., King, Nigel, Brooks, J.; id_orcid, Brooks, Joanna, Hughes, P, Ingleton, Christine, Brooks, J., Winslow, M, King, N., Noble, B., Woolmore, A., Bravington, A., Bath, P.A., Bath, P. A., Ingleton, C., Melvin, J., Hughes, P.   +16 more
core   +1 more source

The adaptation of the therapeutic effort: science, technology and society

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018
The scientific and technological development has an impact in all the spheres of society. The adaptation of the therapeutic effort is example of this. The author’s motive to carry out this bibliographic review article laid on the technological abuse as a
Gilberto de Jesús Betancourt-Betancourt, Gilberto Lázaro Betancourt-Reyes, Nguyen Castro-Gutierrez   +2 more
doaj