Results 121 to 130 of about 17,240,228 (299)

Is dexmedetomidine superior to non-dexmedetomidine sedatives (particularly propofol) for sedation in critically ill patients with septic shock? A systematic review and meta-analysis of randomized controlled trials

Frontiers in Medicine
BackgroundDexmedetomidine (DEX) and propofol (PROP) are both recommended as first-line short-acting sedative-analgesic agents for sepsis patients. However, existing studies have reported inconsistent clinical outcomes potentially attributable to their ...
Xinjing Gao, Xinjing Gao, Xinjing Gao, Xinjing Gao, Zhaoting Li, Zhibo Li, Zhibo Li, Zhibo Li, Zhibo Li, Yingzhi Qin, Yingzhi Qin, Yingzhi Qin, Yingzhi Qin, Jie Ren, Kai Zhang, Wenjiao Wang, Wenjiao Wang, Wenjiao Wang, Wenjiao Wang   +18 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Leveraging large language models to mimic domain expert labeling in unstructured text-based electronic healthcare records in non-english languages

BMC Medical Informatics and Decision Making
Background The integration of big data and artificial intelligence (AI) in healthcare, particularly through the analysis of electronic health records (EHR), presents significant opportunities for improving diagnostic accuracy and patient outcomes ...
Izzet Turkalp Akbasli, Ahmet Ziya Birbilen, Ozlem Teksam   +2 more
doaj   +1 more source

Life Support Systems in Intensive Care [PDF]

Mayo Clinic Proceedings, 1985
John C. McMichan, Rolf D. Hubmayr
  +4 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Commentary: Serum total bilirubin with hospital survival in adults during extracorporeal membrane oxygenation

Frontiers in Medicine, 2022
Chunxia Wang, Chunxia Wang, Chunxia Wang, Yucai Zhang, Yucai Zhang, Yucai Zhang   +5 more
doaj   +1 more source

Self-Care and Family Support Improves the Quality of Life of Coronary Heart Disease Patients

NERS Jurnal Keperawatan
Coronary heart disease (CHD) can reduce the patient's quality of life. An important aspect in influencing the quality of life for CHD patients is self-care and family support for CHD patients, but this is often overlooked.
Emil Huriani, Rifdatul Jannah, Dally Rahman   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The relationship between work and non-work support and work-life balance in Taiwan [PDF]

, 2009
The aim of this study is to explore the relationship between employees' supportive resource (workplace support and non-work support) and their work-life balance in Taiwan.
Chang, Ruby Yi-Ju
core