Results 131 to 140 of about 1,917,089 (269)

Cancer patients' care at the end of life in a critical care environment: perspectives of families, patients and practitioners

Innovations in cancer care requiring intensive support, and improved cancer patient survival in and out of critical care, have led to greater numbers of cancer patients than ever accessing critical care.
Pattison, Natalie
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The relationship between work and non-work support and work-life balance in Taiwan

, 2009
The aim of this study is to explore the relationship between employees' supportive resource (workplace support and non-work support) and their work-life balance in Taiwan.
Chang, Ruby Yi-Ju
core  

Leveraging large language models to mimic domain expert labeling in unstructured text-based electronic healthcare records in non-english languages

BMC Medical Informatics and Decision Making
Background The integration of big data and artificial intelligence (AI) in healthcare, particularly through the analysis of electronic health records (EHR), presents significant opportunities for improving diagnostic accuracy and patient outcomes ...
Izzet Turkalp Akbasli, Ahmet Ziya Birbilen, Ozlem Teksam   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Specialist foster care for traumatised young people with challenging behaviour: Appraising joined up service provision

, 2005
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.It is recognised that looked after young people with a history of trauma, offending, emotional, behavioural and educational difficulties often face a high ...
Brady, Lynn
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Changes in perceived distress among patients receiving inpatient palliative care

Context Understanding the impact of palliative care on patient outcomes is crucial for enhancing end-of-life care. Objectives This study aimed to examine changes in perceived distress among patients receiving inpatient palliative care.
Yu, Chao-Hung;Chen, Chun-Min;Lin, Ying-Li
core   +1 more source

Commentary: Serum total bilirubin with hospital survival in adults during extracorporeal membrane oxygenation

Frontiers in Medicine, 2022
Chunxia Wang, Chunxia Wang, Chunxia Wang, Yucai Zhang, Yucai Zhang, Yucai Zhang   +5 more
doaj   +1 more source

Is dexmedetomidine superior to non-dexmedetomidine sedatives (particularly propofol) for sedation in critically ill patients with septic shock? A systematic review and meta-analysis of randomized controlled trials

Frontiers in Medicine
BackgroundDexmedetomidine (DEX) and propofol (PROP) are both recommended as first-line short-acting sedative-analgesic agents for sepsis patients. However, existing studies have reported inconsistent clinical outcomes potentially attributable to their ...
Xinjing Gao, Xinjing Gao, Xinjing Gao, Xinjing Gao, Zhaoting Li, Zhibo Li, Zhibo Li, Zhibo Li, Zhibo Li, Yingzhi Qin, Yingzhi Qin, Yingzhi Qin, Yingzhi Qin, Jie Ren, Kai Zhang, Wenjiao Wang, Wenjiao Wang, Wenjiao Wang, Wenjiao Wang   +18 more
doaj   +1 more source