Results 151 to 160 of about 17,240,228 (299)

Decision aids for life-sustaining treatment, including withholding or withdrawal and end-of-life care in emergency and intensive care settings: a scoping review protocol. [PDF]

BMJ Open
Tsubaki M, Saito K, Kanayasu H, Ikari R, Yamamoto K, Yamane A, Ito Y.   +6 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Palliative care in the intensive care unit: fundamental aspects, ethical frameworks, and challenges in the Brazilian context. [PDF]

Front Med (Lausanne)
Gomes BC, Basile Filho A, Silva JM.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

SUPPORTING CARING AND CARERS IN LATER LIFE [PDF]

Innovation in Aging, 2017
openaire   +1 more source

Operational Ethics in the Cardiovascular Intensive Care Unit: A Practical Framework for Ethical Decision-Making. [PDF]

J Clin Med
Vicent L, Salguero-Bodes R, R Alonso P, Puerto E, Diaz-Arocutipa C, Arribas Ynsaurriaga F, Martín-Asenjo R.   +6 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Does vitamin D status impact mortality from SARS-CoV-2 infection?

Medicine in Drug Discovery, 2020
Paul E. Marik, Pierre Kory, Joseph Varon
doaj   +1 more source

Care Needs of Patients With Chronic Cardiovascular Diseases: An Integrative Review. [PDF]

Health Sci Rep
Nabi Foodani M, Zakerimoghadam M, Ghiyasvandian S, Márquez Hernández VV, Rodríguez-García MC, Goudarzian AH, Abbasi Dolatabadi Z.   +6 more
europepmc   +1 more source