Results 151 to 160 of about 6,730,594 (397)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Leveraging large language models to mimic domain expert labeling in unstructured text-based electronic healthcare records in non-english languages

BMC Medical Informatics and Decision Making
Background The integration of big data and artificial intelligence (AI) in healthcare, particularly through the analysis of electronic health records (EHR), presents significant opportunities for improving diagnostic accuracy and patient outcomes ...
Izzet Turkalp Akbasli, Ahmet Ziya Birbilen, Ozlem Teksam   +2 more
doaj   +1 more source

Epidemiology of Pediatric Prehospital Basic Life Support Care in the United States

Prehospital Emergency Care, 2016
L. Diggs, Manasi Sheth-Chandra, G. De Leo   +2 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Is dexmedetomidine superior to non-dexmedetomidine sedatives (particularly propofol) for sedation in critically ill patients with septic shock? A systematic review and meta-analysis of randomized controlled trials

Frontiers in Medicine
BackgroundDexmedetomidine (DEX) and propofol (PROP) are both recommended as first-line short-acting sedative-analgesic agents for sepsis patients. However, existing studies have reported inconsistent clinical outcomes potentially attributable to their ...
Xinjing Gao, Xinjing Gao, Xinjing Gao, Xinjing Gao, Zhaoting Li, Zhibo Li, Zhibo Li, Zhibo Li, Zhibo Li, Yingzhi Qin, Yingzhi Qin, Yingzhi Qin, Yingzhi Qin, Jie Ren, Kai Zhang, Wenjiao Wang, Wenjiao Wang, Wenjiao Wang, Wenjiao Wang   +18 more
doaj   +1 more source

Knowledge and attitudes among young adults attending Basic Life Support training in a tertiary care institution [PDF]

, 2019
Varghese George, Rajalakshmi Aiyappan, Sherin Billy Abraham, Rajeev Aravindakshan   +3 more
openalex   +1 more source

Role of the community nurse in supporting person-centred end of life care [PDF]

, 2022
Tracy Smith, Katarzyna A Patynowska, Noreen Reid, Melanie Harvey, Audrey Rowe   +4 more
openalex   +1 more source

Adult Advanced Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations

Resuscitation, 2020
J. Soar, K. Berg, L. Andersen, B. Böttiger, Sofia Cacciola, C. Callaway, K. Couper, T. Cronberg, Sonia D’Arrigo, C. Deakin, M. Donnino, I. Drennan, A. Granfeldt, C. Hoedemaekers, M. Holmberg, Cindy H. Hsu, M. Kamps, Szymon Musiol, K. Nation, R. Neumar, T. Nicholson, B. O’Neil, Quentin Otto, E. F. de Paiva, M. Parr, J. Reynolds, C. Sandroni, B. Scholefield, M. Skrifvars, Tzong-Luen Wang, W. Wetsch, J. Yeung, P. Morley, L. Morrison, M. Welsford, M. Hazinski, J. Nolan, Issa Monica E. Giuseppe Julie Justin L. Maureen Bryan L Mahmoud Kleinman Ristagno Arafeh Benoit Chase Fisc, Issa Mahmoud, Monica E. Kleinman, Giuseppe Ristagno, J. Arafeh, Justin L. Benoit, M. Chase, Bryan L. Fischberg, Gustavo E. Flores, Mark Link, J. Ornato, Sarah M. Perman, C. Sasson, C. Zelop   +50 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Living well while providing support: validation of LTCQ-Carer for assessing informal carers’ quality of life [PDF]

, 2023
Caroline Potter, Michele Peters, Maureen Cundell, Rupert McShane, Ray Fitzpatrick   +4 more
openalex   +1 more source