Results 121 to 130 of about 3,209,297 (289)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

On models for the estimation of the excess mortality hazard in case of insufficiently stratified life tables. [PDF]

Biostatistics, 2021
Rubio FJ, Rachet B, Giorgi R, Maringe C, Belot A.   +4 more
europepmc   +1 more source

A model for geographical variation in health and total life expectancy [PDF]

This paper develops a joint approach to life and health expectancy based on 2001 UK Census data for limiting long term illness and general health status, and on registered death occurrences in 2001.
Peter Congdon
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Regression Models and Multivariate Life Tables. [PDF]

J Am Stat Assoc, 2021
Prentice RL, Zhao S.
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Fitness comparison of Plutella xylostella on original and marginal hosts using age-stage, two-sex life tables. [PDF]

Ecol Evol, 2021
Yang FY, Chen JH, Ruan QQ, Wang BB, Jiao L, Qiao QX, He WY, You MS.   +7 more
europepmc   +1 more source

Life expectancy is the death-weighted average of the reciprocal of the survival-specific force of mortality [PDF]

The hazard of mortality is usually presented as a function of age, but can be defined as a function of the fraction of survivors. This definition enables us to derive new relationships for life expectancy.
Joel E. Cohen
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Race/Ethnicity may be an Important Predictor of Life Expectancy in Localized Prostate Cancer Patients: Novel Analyses Using Social Security Administration Life Tables. [PDF]

J Racial Ethn Health Disparities, 2023
Würnschimmel C, Nocera L, Wenzel M, Ruvolo CC, Tian Z, Saad F, Briganti A, Shariat SF, Mirone V, Chun FKH, Tilki D, Graefen M, Karakiewicz PI.   +12 more
europepmc   +1 more source