Results 131 to 140 of about 14,125,984 (386)

The rate of telomere loss is related to maximum lifespan in birds

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2018
Telomeres are highly conserved regions of DNA that protect the ends of linear chromosomes. The loss of telomeres can signal an irreversible change to a cell's state, including cellular senescence.
Gianna M Tricola   +25 more
semanticscholar   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

open access: yesArthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry   +2 more
wiley   +1 more source

Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

open access: yesGenome Biology, 2017
Background Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by ...
Tina Wang   +9 more
doaj   +1 more source

Adaptation, stress, and coping in sport [PDF]

open access: yes
Adaptation, which was mentioned within the domain of stress and coping research by Lazarus (1991), refers to the way in which people change according to the world that they live in.
Nicholls, Adam
core   +1 more source

Ageism in Rheumatology: the Healthcare Professional's Perspective

open access: yesArthritis Care &Research, Accepted Article.
Objective Ageism (age‐based stereotypes, prejudice, or discrimination) is prevalent and linked to prolonged disability and reduced lifespan in older adults. Little is known about ageism within rheumatology. This study explores the healthcare professional's (HCP) perception of the care of older adults and how ageist attitudes or perspectives may impact ...
Aaron P. Smith   +4 more
wiley   +1 more source

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

open access: yesAdvanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe   +4 more
wiley   +1 more source

The threshold age of Keyfitz' entropy [PDF]

open access: yesarXiv, 2019
BACKGROUND Indicators of relative inequality of lifespans are important because they capture the dimensionless shape of aging. They are markers of inequality at the population level and express the uncertainty at the time of death at the individual level. In particular, Keyfitz' entropy $\bar{H}$ represents the elasticity of life expectancy to a change
arxiv  

Limited Lifespan vs. Perpetuity: Foundation Survey [PDF]

open access: yes, 2009
Survey gathering information about characteristics of foundations existing in perpetuity vs. foundations with a limited lifespan.

core  

Openness to Experience and Culture-Openness Transactions Across the Lifespan

open access: yesJournal of Personality and Social Psychology, 2018
We examined the life span development of openness to experience and tested whether change in this personality trait was associated with change in cultural activity, such as attending the opera or visiting museums.
T. Schwaba   +4 more
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

open access: yesAdvanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi   +4 more
wiley   +1 more source

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