Results 31 to 40 of about 73,179 (247)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Study on Fuel Estimation Algorithms for a Geostationary Communication & Broadcasting Satellite [PDF]

Journal of Astronomy and Space Sciences, 2000
It has been developed to calculate fuel budget for a geostationary communication and broadcasting satellite. It is quite essential that the pre-launch fuel budget estimation must account for the deterministic transfer and drift orbit maneuver ...
Jong Won Eun
doaj  

Influence of Quality of Mounting Process of RF Transistors on Their Thermal Parameters and Lifetime

Applied Sciences, 2022
The paper presents the results of investigations illustrating the influence of imperfections in the soldering process on thermal properties of transistors operating in RF (Radio Frequency) systems.
Krzysztof Górecki, Wojciech Kowalke, Przemysław Ptak   +2 more
doaj   +1 more source

Positron lifetime calculations for defects in Zn

Journal of Physics: Condensed Matter, 2000
Comment: 9 pages, 4 figures, 2 ...
Campillo, J. M., Plazaola, F., de Diego, N.   +2 more
openaire   +2 more sources

The methodology of a part lifetime calculation

IOP Conference Series: Materials Science and Engineering, 2020
Abstract Reducing mills in piece-reduction at the moment of capturing the pipe’s front end and on the rear end exit are exposed to increased dynamic loads. However these processes at present time are not fully researched. The relevant problem is to decrease dynamic loads in the clamp engine, to increase reliability and durability of the ...
Chumakova, L. A., Bulganina, M. Y., Alexandrova, A. S.   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Simplification of the rolling contact-related lifetime calculation of profiled rail guides with a polynomial regression

Journal of Machine Engineering
The calculation of the lifespan of profile rail guides is an essential part in the design process of machines. Conventional lifespan models yield good results when calculating lifespan values under a homogeneous distribution of individual rolling contact
Danny Staroszyk, Müller Jens, Ihlenfeldt Steffen   +2 more
doaj   +1 more source

DDRS4PALS: A software for the acquisition and simulation of lifetime spectra using the DRS4 evaluation board

SoftwareX, 2019
Lifetime techniques are applied to diverse fields of study including materials sciences, semiconductor physics, biology, molecular biophysics and photochemistry.Here we present DDRS4PALS, a software for the acquisition and simulation of lifetime spectra ...
Danny Petschke, Torsten E.M. Staab
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source