Results 51 to 60 of about 80,393 (300)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Influence of Quality of Mounting Process of RF Transistors on Their Thermal Parameters and Lifetime

open access: yesApplied Sciences, 2022
The paper presents the results of investigations illustrating the influence of imperfections in the soldering process on thermal properties of transistors operating in RF (Radio Frequency) systems.
Krzysztof Górecki   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

DDRS4PALS: A software for the acquisition and simulation of lifetime spectra using the DRS4 evaluation board

open access: yesSoftwareX, 2019
Lifetime techniques are applied to diverse fields of study including materials sciences, semiconductor physics, biology, molecular biophysics and photochemistry.Here we present DDRS4PALS, a software for the acquisition and simulation of lifetime spectra ...
Danny Petschke, Torsten E.M. Staab
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A Study on Fuel Estimation Algorithms for a Geostationary Communication & Broadcasting Satellite [PDF]

open access: yesJournal of Astronomy and Space Sciences, 2000
It has been developed to calculate fuel budget for a geostationary communication and broadcasting satellite. It is quite essential that the pre-launch fuel budget estimation must account for the deterministic transfer and drift orbit maneuver ...
Jong Won Eun
doaj  

An Information Theoretic Evaluation of Software Metrics for Object Lifetime Prediction [PDF]

open access: yes, 2008
Accurate object lifetime prediction can be exploited by allocators to improve the performance of generational garbage collection by placing immortal or long-lived objects directly into immortal or old generations.
Watson, Ian   +6 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Residual Lifetime Prediction for Multi-State System Using Control Charts to Monitor Affecting Noise Factor on Deterioration Process

open access: yesJournal of Applied Research on Industrial Engineering, 2018
In this research, multi-state complex systems are analyzed in order to measure reliability and predict residual of systems’ lifetime under the effect of an out of control noise factor.
Neda Gol-Ahmadi, Sadigh Raissi
doaj   +1 more source

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