Results 71 to 80 of about 484,828 (297)
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
机车电传动, 2019 IGBT module is the core component of the train traction converter, its life prediction technology is an important basis for the prognostic and health management of the whole train.
Lin CAO +5 more
doaj
Substantiation of FAC rate and service life estimation under operation control data
Nuclear Energy and Technology, 2016 Flow-accelerated corrosion (FAC) wear is the complex mechanism of damage of elements of NPP equipment and pipelines. FAC rate is determined by such factors as corrosion of metal, flow hydrodynamics, geometry of equipment elements and pipelines, applied ...
V.I. Baranenko +3 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Lifetime and transition probabilities of Np4 - /n plus 1/ p states of Ne 2, A 2, and Kr 2 [PDF]
Calculation of lifetime and transition probability of p-excited states of neon, argon, and ...
Koozekanani, S. H., Trusty, G. L.
core +1 more source
Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz +3 more
wiley +1 more source
Soil Load on Plastic Pipe and its Influence on Lifetime
Journal of Mechanical Engineering, 2019 Lifetime of plastic pipes can be estimated by integration of a power law describing the crack kinetics. However, this procedure requires an FEM (finite element method) calculation of the possible crack propagation in the pipe to obtain stress intensity ...
Poduška Jan +6 more
doaj +1 more source
Lifetime Analysis of IGBT Power Modules in Passively Cooled Tidal Turbine Converters
Energies, 2020 Thermal cycling is one of the major reasons for failure in power electronic converters. For submerged tidal turbine converters investigating this failure mode is critical in improving the reliability, and minimizing the cost of energy from tidal turbines.
Faisal Wani +6 more
doaj +1 more source