Results 31 to 40 of about 71,999 (265)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Fast data augmentation for battery degradation prediction

Energy and AI
Degradation prediction for lithium-ion batteries using data-driven methods requires high-quality aging data. However, generating such data, whether in the laboratory or the field, is time- and resource-intensive.
Weihan Li, Harshvardhan Samsukha, Bruis van Vlijmen, Lisen Yan, Samuel Greenbank, Simona Onori, Venkat Viswanathan   +6 more
doaj   +1 more source

Computational Modeling of Diffusion-Based Delamination for Active Implantable Medical Devices

Bioengineering, 2023
Delamination at heterogeneous material interfaces is one of the most prominent failure modes in active implantable medical devices (AIMDs). A well-known example of an AIMD is the cochlear implant (CI).
Minh-Hai Nguyen, Adrian Onken, Anika Wulff, Katharina Foremny, Patricia Torgau, Helmut Schütte, Sabine Hild, Theodor Doll   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Establishing Li-acetylide (Li2C2) as functional element in solid-electrolyte interphases in lithium-ion batteries

Journal of Power Sources Advances
Previously, lithium-acetylide (Li2C2) had been identified as electrolyte degradation product on lithium-metal based electrodes using Raman spectroscopy. This raised the question, if Li2C2 is also be formed on graphitic electrodes in lithium-ion batteries
Viviane Maccio-Figgemeier, Gebrekidan Gebresilassie Eshetu, Damian Mroz, Hyunsang Joo, Egbert Figgemeier   +4 more
doaj   +1 more source

Lifetime prediction of a multi-chip high-power LED light source based on artificial neural networks

Results in Physics, 2019
A high power light-emitting diodes (LED) light source, which is assembled by many LED chips and heat sink, has a not uniform temperature distribution at working condition.
Hongwei Liu, Dandan Yu, Pingjuan Niu, Zanyun Zhang, Kai Guo, Di Wang, Jianxin Zhang, Xin Ma, Chengkui Jia, Chaoyu Wu   +9 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Cross‐Scale Decoupling Kinetic Processes in Lithium‐Ion Batteries Using the Multi‐Dimensional Distribution of Relaxation Time

Advanced Science
To non‐destructively resolve and diagnose the degradation mechanisms of lithium‐ion batteries (LIBs), it is necessary to cross‐scale decouple complex kinetic processes through the distribution of relaxation times (DRT). However, LIBs with low interfacial
Xue Cai, Caiping Zhang, Haijun Ruan, Zeping Chen, Linjing Zhang, Dirk Uwe Sauer, Weihan Li   +6 more
doaj   +1 more source

Machine learning for battery quality classification and lifetime prediction using formation data

Energy and AI
Accurate classification of battery quality and prediction of battery lifetime before leaving the factory would bring economic and safety benefits. Here, we propose a data-driven approach with machine learning to classify the battery quality and predict ...
Jiayu Zou, Yingbo Gao, Moritz H. Frieges, Martin F. Börner, Achim Kampker, Weihan Li   +5 more
doaj   +1 more source