Results 41 to 50 of about 1,970,939 (305)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Lifetime Evaluation of Traction Converter IGBT Based on Operating Conditions and Component Aging

Kongzhi Yu Xinxi Jishu, 2022
IGBT's lifetime is greatly influenced by the operation conditions of train and the current aging degree of IGBT. However, the influences of train operation conditions and current life of an IGBT on the life assessment are normally not considered.
LI Dong, HE Haopeng, PENG Yangbin, XIN Kaiyue, YAO Xianping, GE Xinlai   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Fast data augmentation for battery degradation prediction

Energy and AI
Degradation prediction for lithium-ion batteries using data-driven methods requires high-quality aging data. However, generating such data, whether in the laboratory or the field, is time- and resource-intensive.
Weihan Li, Harshvardhan Samsukha, Bruis van Vlijmen, Lisen Yan, Samuel Greenbank, Simona Onori, Venkat Viswanathan   +6 more
doaj   +1 more source

Lifetime evaluation of concrete structures under sustained post-peak loading [PDF]

, 2005
Experimental tests on crack propagation in concrete under constant post-peak loading are simulated using the finite element method and the cohesive crack model, in both Mode I and Mixed-mode conditions.
Silvio Valente, Fabrizio Barpi, Barpi, Fabrizio, Valente, Silvio   +3 more
core   +1 more source

Semi-supervised self-learning-based lifetime prediction for batteries

, 2023
Accurate and reliable degradation and lifetime prediction for lithium-ion batteries is the main challenge for smart prognostic and health management.
Stroe, Daniel Ioan; id_orcid, Hu, Xiaosong, Che, Yunhong, Teodorescu, Remus; id_orcid   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Establishing Li-acetylide (Li2C2) as functional element in solid-electrolyte interphases in lithium-ion batteries

Journal of Power Sources Advances
Previously, lithium-acetylide (Li2C2) had been identified as electrolyte degradation product on lithium-metal based electrodes using Raman spectroscopy. This raised the question, if Li2C2 is also be formed on graphitic electrodes in lithium-ion batteries
Viviane Maccio-Figgemeier, Gebrekidan Gebresilassie Eshetu, Damian Mroz, Hyunsang Joo, Egbert Figgemeier   +4 more
doaj   +1 more source

Lifetime prediction of a multi-chip high-power LED light source based on artificial neural networks

Results in Physics, 2019
A high power light-emitting diodes (LED) light source, which is assembled by many LED chips and heat sink, has a not uniform temperature distribution at working condition.
Hongwei Liu, Dandan Yu, Pingjuan Niu, Zanyun Zhang, Kai Guo, Di Wang, Jianxin Zhang, Xin Ma, Chengkui Jia, Chaoyu Wu   +9 more
doaj   +1 more source

Reliability Analysis and Design of MMC Based on Mission Profile for the Components Degradation

IEEE Access, 2020
In the field of high voltage level applications, modular multi-level converter (MMC) has the definite advantages of low power loss and modularity and there have been many studies on its reliability.
Gaotai Lv, Wanjun Lei, Meng Wang, Chunlin Lv, Jiaqi Zhao   +4 more
doaj   +1 more source