Results 71 to 80 of about 237,722 (291)

Methods for Conjugating Antibodies with Quantum Dots

Molecules
Nanomaterials are increasingly used in the development of detection systems for various disease biomarkers as tools for reliable early diagnosis, which is a key factor in reducing mortality and increasing treatment effectiveness.
Pavel Sokolov, Alexander Knysh, Irina Kriukova, Pavel Samokhvalov, Yury V. Kistenev   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Multilevel Analysis of the Neovascularization and Integration Process of a Nonvascularized Rectus Fascia Transplantation

Transplantation Direct
Background. Failure to close the abdominal wall after intestinal transplantation (ITx) or multivisceral Tx remains a surgical challenge. An attractive method is the use of nonvascularized rectus fascia (NVRF) in which both layers of the donor abdominal ...
Ewout Muylle, BSc, Arne Maes, MSc, Gert De Hertogh, MD, PhD, Nele Van De Winkel, MD, Greet Kerckhofs, PhD, Antoine Dubois, MD, Vincent Vandecaveye, MD, PhD, Lieven Thorrez, PhD, Ina Hennion, MSc, Marie-Paule Emonds, MD, PhD, Steven Pans, MD, Nathalie P. Deferm, MD, Diethard Monbaliu, MD, PhD, Emilio Canovai, MD, PhD, Tim Vanuytsel, MD, PhD, Jacques Pirenne, MD, PhD, Laurens J. Ceulemans, MD, PhD   +16 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effects of turbulence modelling on the analysis and optimisation of high-lift configurations [PDF]

, 2011
Due to the significant effects on the performance and competitiveness of aircraft, high lift devices are of extreme importance in aircraft design. The flow physics of high lift devices is so complex, that traditional one pass and multi-pass design ...
Guo, Chuanliang.
core  

Influence of Climate and Land Use Change on Runoff in Xiying River

Land
In arid inland river basins, the upstream runoff generation zones contribute the majority of the basin’s water resources. Global warming and land use changes will produce uncertain impacts on runoff variations in the headwaters of inland rivers in arid ...
Peizhong Yan, Qingyang Wang, Jianjun Wang, Jianqing Peng, Guofeng Zhu   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Presentation of the LIFT project

, 2021
Presentation of the LIFT project one year before the end of the ...
Latruffe, Laure
core   +1 more source

Disparities in being able to donate human milk impacts upon maternal wellbeing: Lessons for scaling up milk bank service provision

Maternal and Child Nutrition
Receiving donor human milk for a baby can have a protective effect upon parental wellbeing. A growing body of research also finds that being able to donate milk to a milk bank, particularly after infant loss, can also boost maternal wellbeing through ...
Amy Brown, Catrin Griffiths, Sara Jones, Gillian Weaver, Natalie Shenker   +4 more
doaj   +1 more source