Results 91 to 100 of about 27,872 (309)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Airfoil Lift Coefficient Optimization Using Genetic Algorithm and IGP Parameterization: Volume 1

, 2023
The objective of this study is to develop a genetic algorithm that uses the IGP parameterization to increase the lift coefficient (CL) of three airfoils to be used on wings of unmanned aerial vehicles (UAVs).
Manuel Alberto Flores-Alfaro, Lorena del Carmen Santos-Cortes, Marco Osvaldo Vigueras-Zúñiga, Miguel Toledo-Velázquez, María Elena Tejeda-del-Cueto, José Hernández-Hernández   +5 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Effect of canard-chordwise blowing on the aerodynamic characteristics of blended wing body aircraft

Xibei Gongye Daxue Xuebao
To enhance the effect of the canard increasing lift and pitching moment coefficient of the blended-wing-body(BWB) aircraft, numerical simulation is adopted to analyze the effect of the canard-chordwise blowing on the low-speed aerodynamic characteristics
YUAN Changyun, XIA Ming, GAO Weicheng, SHI Weifeng, GONG Wenxiu, YUAN Haoqian   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Suppression of flow separation of a high-lift wing with active flow control

Flow separation caused by the integration of a leading edge slat cut-out to accommodate an ultra-high bypass ratio engine reduces the maximum lift coefficient.
Stefes, Bruno, Jabbal, Mark, Jefferson-Loveday, Richard, Sun, Qiangqiang, Bahri, Faycal, Stryczniewicz, Wit, Büscher, Alexander   +6 more
core   +1 more source

Study of 3D Flapped CoFlow Jet Wings for Ultra-High Cruise Lift Coefficient

, 2023
The previous research indicates a possibility of increasing subsonic 2D airfoil cruise lift coefficient C-L by an order of magnitude from 0.4 to 4 with a flapped coflow jet airfoil modified from CFJ-NACA-6421 airfoil at a reasonable aerodynamic ...
Zha, Gecheng, Ren, Yan, McBreen, Brendon, Jeon, Jaehyoung   +3 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

NUMERICAL SIMULATION OF FLOW ROUND FREE SPANNING SUBMARINE PIPELINE AT HIGH REYNOLDS NUMBER

Jixie qiangdu, 2018
Free spanning submarine pipeline work in the harsh condition and has many failure modes. Vortex-induced vibration is a significant cause leading to its fatigue failure.
HU Qin, WAN ChangCheng, XIAO Xiang, WANG Chuan   +3 more
doaj