Results 71 to 80 of about 22,309 (312)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Effect of canard-chordwise blowing on the aerodynamic characteristics of blended wing body aircraft

Xibei Gongye Daxue Xuebao
To enhance the effect of the canard increasing lift and pitching moment coefficient of the blended-wing-body(BWB) aircraft, numerical simulation is adopted to analyze the effect of the canard-chordwise blowing on the low-speed aerodynamic characteristics
YUAN Changyun, XIA Ming, GAO Weicheng, SHI Weifeng, GONG Wenxiu, YUAN Haoqian   +5 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Measuring method of drag coefficient, lift coefficient and equivalent roughness of revetment block

PROCEEDINGS OF HYDRAULIC ENGINEERING, 2000
This study examines measuring methods of drag coefficient, lift coefficient and equivalent roughness that are necessary for mechanical design of revetment blocks set on river banks. The setting method of blocks and the influence of the Reynolds number on drag force and lift force are examined by checking the experimental results.
YAMAMOTO, Kouichi, HAYASI, Kenjirou, SENKINE, Masato, FUJITA, Kouichi, TAMURA, Masahide, NISIMURA, Susumu, HAMAGUCHI, Kenichirou   +6 more
openaire   +2 more sources

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

NUMERICAL SIMULATION OF FLOW ROUND FREE SPANNING SUBMARINE PIPELINE AT HIGH REYNOLDS NUMBER

Jixie qiangdu, 2018
Free spanning submarine pipeline work in the harsh condition and has many failure modes. Vortex-induced vibration is a significant cause leading to its fatigue failure.
HU Qin, WAN ChangCheng, XIAO Xiang, WANG Chuan   +3 more
doaj  

Aerodynamic Analysis of Rigid Wing Sail Based on CFD Simulation for the Design of High-Performance Unmanned Sailboats

Mathematics
The utilization of unmanned sailboats as a burgeoning instrument for ocean exploration and monitoring is steadily rising. In this study, a dual sail configuration is put forth to augment the sailboats’ proficiency in its wind-catching ability and adapt ...
Shipeng Fang, Cunwei Tian, Yuqi Zhang, Changbin Xu, Tianci Ding, Huimin Wang, Tao Xia   +6 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

LIFT AND DRAG COEFFICIENTS FOR DIFFERENT MAGNUS ROTOR TYPES

Journal of Energy Technology
In this paper, the results of numerical simulations for various Magnus rotor configurations are presented. For each configuration, a blocked structured mesh was designed in ICEM CFD. Numerical simulations were conducted using Ansys CFX. The influence of the aspect ratio on the lift and drag coefficients depending on the speed ratio was investigated, as
openaire   +2 more sources