Results 51 to 60 of about 22,309 (312)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Inertial coefficient rings and the idempotent lifting property [PDF]
Proceedings of the American Mathematical Society, 1976 A commutative ring R R with identity is called an inertial coefficient ring if ...
openaire +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Aerodynamic Forces Acting on a Race Car for Various Ground Clearances and Rake Angles
Journal of Applied Fluid Mechanics, 2019 Computational model was developed to investigate aerodynamic forces acting on a closed-wheel race car. A particular focus was on the effects of ground clearance and rake angle on aerodynamic drag and lift forces.
I. Džijan +3 more
doaj +2 more sources
Aerodynamic Characterization of Bullet Heads with Different Arcuate Curves [PDF]
Journal of Applied Fluid MechanicsThe bullet shape is critical in efficient bullet design because it affects the lift and drag forces. This paper proposes a new bullet shape with a logarithmic curve and analyzes the lift and drag coefficients of bullets with different curves under ...
B. Hao, Q. Jiang, C. Xu, L. Liu
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Aerodynamic Characteristics of UAV Taking Off and Landing from Water Surface with Multi-Segment Wing in Ground Effect [PDF]
Hangkong bingqiIn order to improve the performance of aerodynamic and take off and landing from water surface, a new biomimetic UAV with multi-segment wing in ground effect is designed based on the hull fuselage, multi-segment wing and T-tai.
Liu Zhanhe, Xia Lulin, Ma Yunpeng, Wang Jing, Zhang Lu, Wu Haokun
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source