Results 41 to 50 of about 208,832 (308)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Aerodynamics of Golf Balls in Still Air

Proceedings, 2018
The following considers lift and drag measurements of 13 production golf ball models propelled through still air in a laboratory setting. The balls travelled at speeds ranging from 18 m/s to 91 m/s and spin ranging from 1500 rpm to 4500 rpm.
Bin Lyu, Jeff Kensrud, Lloyd Smith, Taylor Tosaya   +3 more
doaj   +1 more source

Hydrodynamic Forces of a Semi-Submerged Cylinder in an Oscillatory Flow

Applied Sciences, 2020
This work experimentally investigated the performance of hydrodynamic forces on a semi-submerged cylinder under an oscillatory flow. To generate the equivalent oscillatory flow, the semi-submerged cylinder is forced to oscillate in several combinations ...
Haojie Ren, Shixiao Fu, Chang Liu, Mengmeng Zhang, Yuwang Xu, Shi Deng   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Enhancing the Efficiency of Horizontal Axis Wind Turbines Through Optimization of Blade Parameters

Journal of Engineering
In this research, we delve into the promising potential of horizontal axis wind turbines to effectively meet the electricity needs of developing countries.
Hossein Seifi Davari, Ruxandra Mihaela Botez, Mohsen Seify Davari, Harun Chowdhury   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Wind Tunnel Experimental Study of Lift Enhancement and Drag Reduction on a Swept Wing Based on a Co-Flow Jet Technique

Applied Sciences
Co-flow jet (CFJ) is an active flow control technique that significantly enhances aerodynamic performance metrics such as the maximum lift and maximum lift-to-drag ratio of airfoils or wings.
Bo Wang, Kai Sun, Xudong Yang, Bifeng Song   +3 more
doaj   +1 more source

NUMERICAL SIMULATION ON REAR SPOILER ANGLE OF MINI MPV CAR FOR CONDUCTING STABILITY AND SAFETY

Jurnal Ilmiah SINERGI, 2019
Spoiler attached on the rear part of a car can generate drag force and negative lift force, called downforce. This drag force can increase air resistance to the car, meanwhile, a negative lift force can improve the car’s stability and safety.
Alief Avicenna Luthfie, Dedik Romahadi, Hanif Ghufron, Solli Dwi Murtyas   +3 more
doaj   +1 more source

Lifting of Coefficients for Chow Motives of Quadrics

, 2010
We prove that the natural functor from the category of Chow motives of smooth projective quadrics with integral coefficients to the category with coefficients modulo 2 induces a bijection on the isomorphism classes of objects.
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source