Results 91 to 100 of about 11,934 (259)

Reduced-order aerodynamic model of a starting plate with discrete-vortex merging

Frontiers in Physics
This study employs potential flow theory with a discrete-vortex method to model the unsteady aerodynamics of a flat plate, with a particular focus on the coupled dynamics of leading-edge and trailing-edge vortices (LEVs and TEVs).
Xi Xia, Lingyun Shangguan
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Enhanced Midface Lift: A Subciliary Incision Approach in Conjunction With Minimal Access Cranial Suspension Lift

Plastic and Reconstructive Surgery - Global Open
Background: Minimal access cranial suspension (MACS) lift is a well-established face lift technique commonly included in the facial plastic surgeon’s armamentarium. It has consistently demonstrated safety and efficacy.
Elsahar, Hatem, Raafat, Sarah Sherif, Ezzat, Sherief Zamer, Khachaba, Youssif A., Nasr, Laila Ahmed Aboul   +4 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Aerodynamic Investigation for a Propeller-Induced Lift-Enhancing Vertical Take-Off and Landing (VTOL) Configuration

Drones
Difficulty in thrust-matching between the cruise and vertical take-off and landing (VTOL) phases is one of the prominent issues faced by conventional VTOL fixed-wing drones.
Hongbo Wang, Guangjia Li, Jie Li, Junjie Zhuang   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Orca hydrofoil shape optimization using Bezier curve and artificial neural network – multiple objective genetic algorithm for low flow velocity

Journal of King Saud University: Engineering Sciences
Tidal energy is a clean and predictable power source commonly harnessed using horizontal-axis tidal turbines. The power generation process of these turbines is influenced by various elements, including the hydrofoil performance metrics such as the lift ...
Muhammad Ihsan Masykur, Harinaldi
doaj   +1 more source