Results 91 to 100 of about 117,271 (297)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Conceptual design, evaluation and research identification for Remote Augmented Propulsive Lift Systems (RALS) with ejectors for VTOL aircraft [PDF]
Ejector concepts for use with a remote augmented lift system (RALS) exhaust nozzle were studied. A number of concepts were considered and three were selected as having the greatest promise of providing the desired aircraft and exhaust gas cooling and ...
Konarski, M. +2 more
core +1 more source
Curious patterns of IR symmetry enhancement
, 2018 We study several cases of IR enhancements of global symmetry in four dimensions. In particular, we consider a sequence of $Spin(n+4)$ supersymmetric gauge theories ($8\geq n\geq 1$) with $n$ vectors and spinor matter with $32$ components.
Razamat, Shlomo S. +2 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Comparative Study of Active Flow Control Strategies for Lift Enhancement of a Simplified High-Lift Configuration [PDF]
Numerical simulations have been performed for a simplified high-lift (SHL) version of the Common Research Model (CRM) configuration, where the Fowler flaps of the conventional high-lift (CRM-HL) configuration are replaced by a set of simple hinged flaps.
Duda, Benjamin +6 more
core +1 more source
Enhanced Euclidean supersymmetry, 11D supergravity and $SU(\infty)$ Toda equation
, 2013 We show how to lift solutions of Euclidean Einstein-Maxwell equations with non-zero cosmological constant to solutions of eleven-dimensional supergravity theory with non-zero fluxes.
Dunajski, Maciej +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Analysis of some aerodynamic characteristics due to wing-jet interaction [PDF]
The results of two separate theoretical investigations are presented. A program was used which is capable of predicting the aerodynamic characteristics of both upper-surface blowing (USB) and over-wing blowing (OWB) configurations. A theoretical analysis
Fillman, G. L., Lan, C. E.
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source