Results 111 to 120 of about 117,271 (297)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Reduced-order aerodynamic model of a starting plate with discrete-vortex merging
Frontiers in PhysicsThis study employs potential flow theory with a discrete-vortex method to model the unsteady aerodynamics of a flat plate, with a particular focus on the coupled dynamics of leading-edge and trailing-edge vortices (LEVs and TEVs).
Xi Xia, Lingyun Shangguan
doaj +1 more source
Broadband Quantum Efficiency Enhancement in High Index Nanowires Resonators
, 2015 Light trapping in sub-wavelength semiconductor nanowires (NWs) offers a promising approach to simultaneously reducing material consumption and enhancing photovoltaic performance.
Hyatt, Steven +3 more
core +1 more source
New F-theory lifts II: permutation orientifolds and enhanced singularities [PDF]
Journal of High Energy Physics, 2010 In this paper, a procedure is developed to construct compact F-theory fourfolds corresponding to perturbative IIB O7/O3 models on CICY threefolds with permutation involutions. The method is explained in generality, and then applied to specific examples where the involution permutes two Del Pezzo surfaces.
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Bio-inspired vortex lift for enhanced manoeuvrability
, 2022 Inspired by highly manoeuvrable species of birds like the peregrine falcon and the swift, static and dynamic computational fluid dynamics (CFD) simulations were conducted to investigate vortex lift in unsteady flows. The configuration corresponds to a 50◦ sweep delta wing with sharp leading edge at Re= 5.0×104.
Dominguez, Alejandro +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Dynamic airfoil stall investigations [PDF]
, 1992 Experimental and computational investigations of the dynamic stall phenomenon continue to attract the attention of various research groups in the major aeronautical research laboratories. There are two reasons for this continued research interest. First,
Carr, L. W. +3 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source