Results 101 to 110 of about 11,934 (259)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Experimental and numerical simulation analysis of the performance of spiral inlet air lift pump

Advances in Mechanical Engineering
To enhance the lifting performance of the air lift pump, this paper introduces a spiral air intake method. Using Fluent software and the VOF model along with the standard k-ε turbulence model, we analyzed the variations in liquid flow rate, lifting ...
Shu Wang, Yong Li, Fengling Yang, Dong Hu, Peng Lin   +4 more
doaj   +1 more source

Aerodynamic design of a double slotted morphed flap airfoil– a numerical study

Frontiers in Mechanical Engineering
Introduction:The objective of this study is to develop and simulate a double slotted morphed flap with the intention of reducing drag and enhancing lift, thereby leading to a smaller flap size and reduced weight.Methods:A flap was meticulously designed ...
S. S. Shahrokhi, M. Taeibi Rahni, P. Akbari   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Numerical Simulation and Experimental Study on the Aerodynamics of Propulsive Wing for a Novel Electric Vertical Take-Off and Landing Aircraft

Aerospace
The electric vertical take-off and landing (eVTOL) aircraft offers the advantages of vertical take-off and landing, environmental cleanliness, and automated control, making it a crucial component of future urban air traffic.
Junjie Wang, Xinfeng Zhang, Jiaxin Lu, Zhengfei Tang   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Bio-inspired vortex lift for enhanced manoeuvrability

, 2022
Inspired by highly manoeuvrable species of birds like the peregrine falcon and the swift, static and dynamic computational fluid dynamics (CFD) simulations were conducted to investigate vortex lift in unsteady flows. The configuration corresponds to a 50◦ sweep delta wing with sharp leading edge at Re= 5.0×104.
Dominguez, Alejandro, Tomé, Joao, Gowree, Erwin Ricky, Bauerheim, Michaël   +3 more
openaire   +1 more source

Gas Lift Optimization for Zubair Oil Field Using Genetic Algorithm-Based Numerical Simulation: Feasibility Study

Iraqi Journal of Chemical and Petroleum Engineering
The gas-lift method is crucial for maintaining oil production, particularly from an established field when the natural energy of the reservoirs is depleted.
Saad Hazem O. Al-Mansory, Omar Al-Fatlawi, Ali Kadkhodaie   +2 more
doaj   +1 more source