Results 121 to 130 of about 117,271 (297)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Aerodynamic Investigation for a Propeller-Induced Lift-Enhancing Vertical Take-Off and Landing (VTOL) Configuration

Drones
Difficulty in thrust-matching between the cruise and vertical take-off and landing (VTOL) phases is one of the prominent issues faced by conventional VTOL fixed-wing drones.
Hongbo Wang, Guangjia Li, Jie Li, Junjie Zhuang   +3 more
doaj   +1 more source

Study of alternative geometries for fluidic oscillators by means of computational fluid mechanics [PDF]

, 2015
Se estudiará el fllujo en el interior de osciladores fluídicos mediante el uso de un código comercial de Mecánica de Fluidos Computacional.Se estudiarán diferentes diseños y se compararán sus rendimientos.1. Documentación y estudio del estado del arte. 2.
Baucells Fuster, Xavier
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Orca hydrofoil shape optimization using Bezier curve and artificial neural network – multiple objective genetic algorithm for low flow velocity

Journal of King Saud University: Engineering Sciences
Tidal energy is a clean and predictable power source commonly harnessed using horizontal-axis tidal turbines. The power generation process of these turbines is influenced by various elements, including the hydrofoil performance metrics such as the lift ...
Muhammad Ihsan Masykur, Harinaldi
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental and numerical simulation analysis of the performance of spiral inlet air lift pump

Advances in Mechanical Engineering
To enhance the lifting performance of the air lift pump, this paper introduces a spiral air intake method. Using Fluent software and the VOF model along with the standard k-ε turbulence model, we analyzed the variations in liquid flow rate, lifting ...
Shu Wang, Yong Li, Fengling Yang, Dong Hu, Peng Lin   +4 more
doaj   +1 more source

Aerodynamic design of a double slotted morphed flap airfoil– a numerical study

Frontiers in Mechanical Engineering
Introduction:The objective of this study is to develop and simulate a double slotted morphed flap with the intention of reducing drag and enhancing lift, thereby leading to a smaller flap size and reduced weight.Methods:A flap was meticulously designed ...
S. S. Shahrokhi, M. Taeibi Rahni, P. Akbari   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source