Results 121 to 130 of about 7,951,401 (343)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Reduced-order aerodynamic model of a starting plate with discrete-vortex merging
Frontiers in PhysicsThis study employs potential flow theory with a discrete-vortex method to model the unsteady aerodynamics of a flat plate, with a particular focus on the coupled dynamics of leading-edge and trailing-edge vortices (LEVs and TEVs).
Xi Xia, Lingyun Shangguan
doaj +1 more source
Analysis of some aerodynamic characteristics due to wing-jet interaction [PDF]
The results of two separate theoretical investigations are presented. A program was used which is capable of predicting the aerodynamic characteristics of both upper-surface blowing (USB) and over-wing blowing (OWB) configurations. A theoretical analysis
Fillman, G. L., Lan, C. E.
core +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
On the spectrum of AdS/CFT beyond supergravity
, 2003 We test the spectrum of string theory on AdS_5 x S^5 derived in hep-th/0305052 against that of single-trace gauge invariant operators in free N=4 super Yang-Mills theory. Masses of string excitations at critical tension are derived by extrapolating plane-
A. Dhar +44 more
core +1 more source
New F-theory lifts II: permutation orientifolds and enhanced singularities [PDF]
Journal of High Energy Physics, 2010 In this paper, a procedure is developed to construct compact F-theory fourfolds corresponding to perturbative IIB O7/O3 models on CICY threefolds with permutation involutions. The method is explained in generality, and then applied to specific examples where the involution permutes two Del Pezzo surfaces.
openaire +2 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Highlights of Supersymmetric Hypercharge $\pm1$ Triplets
, 2013 The discovery of a standard model (SM)-like Higgs boson with a relatively heavy mass $m_h$ and hints of di-photon excess has deep implication to supersymmetric standard models (SSMs).
Kang, Zhaofeng +2 more
core +1 more source
Bio-inspired vortex lift for enhanced manoeuvrability
, 2022 Inspired by highly manoeuvrable species of birds like the peregrine falcon and the swift, static and dynamic computational fluid dynamics (CFD) simulations were conducted to investigate vortex lift in unsteady flows. The configuration corresponds to a 50◦ sweep delta wing with sharp leading edge at Re= 5.0×104.
Dominguez, Alejandro +3 more
openaire +1 more source