Results 1 to 10 of about 369,161 (297)

Biochemistry of the Endogenous Ligands of Cannabinoid Receptors

Neurobiology of Disease, 1998
In 1992 the discovery of the first endogenous ligand of cannabinoid receptors, anandamide, provided conclusive support to the hypothesis that an "endogenous cannabinoid regulatory system" exists in mammalian nervous tissue. Anandamide (N-arachidonoyl-ethanolamine) was the first of a series of long-chain fatty acid derivatives, including two other ...
Dale G. Deutsch, V. Di Marzo
openaire   +4 more sources

Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation [PDF]

PeerJ, 2021
GPCRs (G-protein coupled receptors) are the largest family of drug targets and share a conserved structure. Binding sites are unknown for many important GPCR ligands due to the difficulties of GPCR recombinant expression, biochemistry, and ...
Ashley Ryan Vidad, Stephen Macaspac, Ho Leung Ng   +2 more
doaj   +2 more sources

Modeling ligand-macromolecular interactions as eigenvalue-based transition-state dissociation constants may offer insights into biochemical function of the resulting complexes

Mathematical Biosciences and Engineering, 2022
A ligand when bound to a macromolecule (protein, DNA, RNA) will influence the biochemical function of that macromolecule. This observation is empirical and attributable to the association of the ligand with the amino acids/nucleotides that comprise the ...
Siddhartha Kundu
doaj   +1 more source

Structural and functional analyses explain Pea KAI2 receptor diversity and reveal stereoselective catalysis during signal perception

Communications Biology, 2022
Guercio et al., combine structural biology, biochemistry, and plant biology to reveal the dual functions of evolutionarily diverged Pisum KAI2A and KAI2B as both receptors and enzymes with distinct ligand selectivity, and propose adaptive sensitivity to ...
Angelica M. Guercio, Salar Torabi, David Cornu, Marion Dalmais, Abdelhafid Bendahmane, Christine Le Signor, Jean-Paul Pillot, Philippe Le Bris, François-Didier Boyer, Catherine Rameau, Caroline Gutjahr, Alexandre de Saint Germain, Nitzan Shabek   +12 more
doaj   +1 more source

Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Pathogenic Candida albicans yeasts frequently cause infections in hospitals. Antifungal drugs lose effectiveness due to other Candida species and resistance. New medications are thus required. Secreted aspartic protease of C.
Jiří Dostál, Jiří Brynda, Lucie Vaňková, Syeda Rehana Zia, Iva Pichová, Olga Heidingsfeld, Martin Lepšík   +6 more
doaj   +1 more source

Detection of the Atherosclerotic PCSK9 gene Inhibitors Through in silico Method to Improve Targeted Therapy

Biology, Medicine & Natural Product Chemistry, 2022
The PCSK9 is one of the most important marks for the evolution of therapeutic agents for atherosclerosis because its interaction with low-density lipoprotein receptors causes atherosclerosis.
Sabarinathan Sethuramalingam, Revathy Leena Ravi, Janet Rani Rajiah   +2 more
doaj   +1 more source

Diagnostic and prognostic significance of cell death markers in patients with cirrhosis and acute decompensation

PLoS ONE, 2022
Background The transition from compensated to decompensated liver cirrhosis is a hallmark of disease progression, however, reliable predictors to assess the risk of decompensation in individual patients from routine diagnostics are lacking.
Philipp Stoffers, Sabrina Guckenbiehl, Martin Walter Welker, Stefan Zeuzem, Christian Markus Lange, Jonel Trebicka, Eva Herrmann, Christoph Welsch   +7 more
doaj   +2 more sources

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]

, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris, Cascio, Duilio, Eisenberg, David S, Esswein, Shannon R, Ly, Alan T, Phillips, Martin L, Salwinski, Lukasz, Sawaya, Michael R   +7 more
core   +1 more source

Matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding

Neural Regeneration Research, 2015
Both matrix biochemistry and neurotrophic factors are known to modulate neurite outgrowth and pathfinding however, the interplay between these two factors is less studied.
Christopher M Madl, Sarah C Heilshorn
doaj   +1 more source

Metallo-intercalators and metallo-insertors [PDF]

, 2007
Since the elucidation of the structure of double helical DNA, the construction of small molecules that recognize and react at specific DNA sites has been an area of considerable interest.
Barton, Jacqueline K., Pierre, Valerie C., Zeglis, Brian M.   +2 more
core   +1 more source