Results 1 to 10 of about 1,329,831 (386)
Reversible ligand binding reactions: Why do biochemistry students have trouble connecting the dots? [PDF]
Biochemistry and Molecular Biology Education, 2007 AbstractAdaptive chemical behavior is essential for an organism's function and survival, and it is no surprise that biological systems are capable of responding both rapidly and selectively to chemical changes in the environment. To elucidate an organism's biochemistry, its chemical reactions need to be characterized in ways that reflect the normal ...
Duane W. Sears +2 more
openalex +4 more sources
Biochemistry of the Endogenous Ligands of Cannabinoid Receptors
Neurobiology of Disease, 1998 In 1992 the discovery of the first endogenous ligand of cannabinoid receptors, anandamide, provided conclusive support to the hypothesis that an "endogenous cannabinoid regulatory system" exists in mammalian nervous tissue. Anandamide (N-arachidonoyl-ethanolamine) was the first of a series of long-chain fatty acid derivatives, including two other ...
Vincenzo Di Marzo, Dale G. Deutsch
openalex +4 more sources
The Journal of Steroid Biochemistry and Molecular Biology, 2011 Shigeaki Kato +3 more
openalex +3 more sources
Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation [PDF]
PeerJ, 2021 GPCRs (G-protein coupled receptors) are the largest family of drug targets and share a conserved structure. Binding sites are unknown for many important GPCR ligands due to the difficulties of GPCR recombinant expression, biochemistry, and ...
Ashley Ryan Vidad +2 more
doaj +2 more sources
Mathematical Biosciences and Engineering, 2022 A ligand when bound to a macromolecule (protein, DNA, RNA) will influence the biochemical function of that macromolecule. This observation is empirical and attributable to the association of the ligand with the amino acids/nucleotides that comprise the ...
Siddhartha Kundu
doaj +1 more source
Communications Biology, 2022 Guercio et al., combine structural biology, biochemistry, and plant biology to reveal the dual functions of evolutionarily diverged Pisum KAI2A and KAI2B as both receptors and enzymes with distinct ligand selectivity, and propose adaptive sensitivity to ...
Angelica M. Guercio +12 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Pathogenic Candida albicans yeasts frequently cause infections in hospitals. Antifungal drugs lose effectiveness due to other Candida species and resistance. New medications are thus required. Secreted aspartic protease of C.
Jiří Dostál +6 more
doaj +1 more source
Regulation of mRNA translation by a photoriboswitch. [PDF]
, 2020 Optogenetic tools have revolutionized the study of receptor-mediated processes, but such tools are lacking for RNA-controlled systems. In particular, light-activated regulatory RNAs are needed for spatiotemporal control of gene expression.
Abdelsayed, Michael M +7 more
core +1 more source