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Protein–Ligand Interactions: Recent Advances in Biophysics, Biochemistry, and Bioinformatics [PDF]
International Journal of Molecular SciencesProtein–ligand interactions result in the formation of complexes between proteins and ligands, which can be small molecules or macromolecules including other proteins [...]
Igor A. Sedov, Yuriy F. Zuev
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Biochemistry of the Endogenous Ligands of Cannabinoid Receptors
Neurobiology of Disease, 1998 In 1992 the discovery of the first endogenous ligand of cannabinoid receptors, anandamide, provided conclusive support to the hypothesis that an "endogenous cannabinoid regulatory system" exists in mammalian nervous tissue. Anandamide (N-arachidonoyl-ethanolamine) was the first of a series of long-chain fatty acid derivatives, including two other ...
Vincenzo Di Marzo, Dale G. Deutsch
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Iron Hydrolysis and the Biochemistry of Iron - The Interplay of Hydroxide and Biogenic Ligands
CHIMIA, 1988 The variety of iron hydroxides that are formed in biological systems is considered in terms of prototype products which have been identified in synthetic media. Polynuclear hydroxy-oxo complexes with highly ordered domains are typically obtained in rather acid solutions of ferric ions whereas from strongly alkaline polyalcohol solutions very small ...
Walter Schneider
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Reversible ligand binding reactions: Why do biochemistry students have trouble connecting the dots? [PDF]
Biochemistry and Molecular Biology Education, 2007 AbstractAdaptive chemical behavior is essential for an organism's function and survival, and it is no surprise that biological systems are capable of responding both rapidly and selectively to chemical changes in the environment. To elucidate an organism's biochemistry, its chemical reactions need to be characterized in ways that reflect the normal ...
Duane W. Sears +2 more
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Journal of Medicinal Chemistry, 1986 N-Allyl-, N-(cyclopropylmethyl)-, and N-propyl-endo-ethenotetrahydronororipavines (N-substituted 6,14-endo-etheno-4,5-epoxy-3-hydroxy-6-methoxymorphinans) were synthesized with potential acylating or alkylating moieties at the C-7 position (isothiocyanato, (bromoacetyl)amino, and (methoxyfumaroyl)amino) and examined in vivo for their narcotic agonist ...
Ralph A. Lessor +9 more
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Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation [PDF]
PeerJ, 2021 GPCRs (G-protein coupled receptors) are the largest family of drug targets and share a conserved structure. Binding sites are unknown for many important GPCR ligands due to the difficulties of GPCR recombinant expression, biochemistry, and ...
Ashley Ryan Vidad +2 more
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Communications Biology, 2022 Guercio et al., combine structural biology, biochemistry, and plant biology to reveal the dual functions of evolutionarily diverged Pisum KAI2A and KAI2B as both receptors and enzymes with distinct ligand selectivity, and propose adaptive sensitivity to ...
Angelica M. Guercio +12 more
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Mathematical Biosciences and Engineering, 2022 A ligand when bound to a macromolecule (protein, DNA, RNA) will influence the biochemical function of that macromolecule. This observation is empirical and attributable to the association of the ligand with the amino acids/nucleotides that comprise the ...
Siddhartha Kundu
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Pathogenic Candida albicans yeasts frequently cause infections in hospitals. Antifungal drugs lose effectiveness due to other Candida species and resistance. New medications are thus required. Secreted aspartic protease of C.
Jiří Dostál +6 more
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