Results 1 to 10 of about 201,977 (89)

Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation [PDF]

PeerJ, 2021
GPCRs (G-protein coupled receptors) are the largest family of drug targets and share a conserved structure. Binding sites are unknown for many important GPCR ligands due to the difficulties of GPCR recombinant expression, biochemistry, and ...
Ashley Ryan Vidad, Stephen Macaspac, Ho Leung Ng   +2 more
doaj   +2 more sources

Structural and functional analyses explain Pea KAI2 receptor diversity and reveal stereoselective catalysis during signal perception

Communications Biology, 2022
Guercio et al., combine structural biology, biochemistry, and plant biology to reveal the dual functions of evolutionarily diverged Pisum KAI2A and KAI2B as both receptors and enzymes with distinct ligand selectivity, and propose adaptive sensitivity to ...
Angelica M. Guercio, Salar Torabi, David Cornu, Marion Dalmais, Abdelhafid Bendahmane, Christine Le Signor, Jean-Paul Pillot, Philippe Le Bris, François-Didier Boyer, Catherine Rameau, Caroline Gutjahr, Alexandre de Saint Germain, Nitzan Shabek   +12 more
doaj   +1 more source

Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Pathogenic Candida albicans yeasts frequently cause infections in hospitals. Antifungal drugs lose effectiveness due to other Candida species and resistance. New medications are thus required. Secreted aspartic protease of C.
Jiří Dostál, Jiří Brynda, Lucie Vaňková, Syeda Rehana Zia, Iva Pichová, Olga Heidingsfeld, Martin Lepšík   +6 more
doaj   +1 more source

Detection of the Atherosclerotic PCSK9 gene Inhibitors Through in silico Method to Improve Targeted Therapy

Biology, Medicine & Natural Product Chemistry, 2022
The PCSK9 is one of the most important marks for the evolution of therapeutic agents for atherosclerosis because its interaction with low-density lipoprotein receptors causes atherosclerosis.
Sabarinathan Sethuramalingam, Revathy Leena Ravi, Janet Rani Rajiah   +2 more
doaj   +1 more source

Resonance Raman Spectroscopy Reveals that Substrate Structure Selectively Impacts the Heme-Bound Diatomic Ligands of CYP17 [PDF]

, 2013
An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids.
Gregory, Michael C., Kincaid, James R., Mak, Piotr J., Sligar, Stephen G.   +3 more
core   +2 more sources

Diagnostic and prognostic significance of cell death markers in patients with cirrhosis and acute decompensation

PLoS ONE, 2022
Background The transition from compensated to decompensated liver cirrhosis is a hallmark of disease progression, however, reliable predictors to assess the risk of decompensation in individual patients from routine diagnostics are lacking.
Philipp Stoffers, Sabrina Guckenbiehl, Martin Walter Welker, Stefan Zeuzem, Christian Markus Lange, Jonel Trebicka, Eva Herrmann, Christoph Welsch   +7 more
doaj   +2 more sources

Matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding

Neural Regeneration Research, 2015
Both matrix biochemistry and neurotrophic factors are known to modulate neurite outgrowth and pathfinding however, the interplay between these two factors is less studied.
Christopher M Madl, Sarah C Heilshorn
doaj   +1 more source

Metallo-intercalators and metallo-insertors [PDF]

, 2007
Since the elucidation of the structure of double helical DNA, the construction of small molecules that recognize and react at specific DNA sites has been an area of considerable interest.
Barton, Jacqueline K., Pierre, Valerie C., Zeglis, Brian M.   +2 more
core   +1 more source

Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins

Frontiers in Neuroscience, 2020
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems.
Thao N. T. Ho, Nikita Abraham, Richard J. Lewis   +2 more
doaj   +1 more source

Plasmodium falciparum rhoptry neck protein 4 has conserved regions mediating interactions with receptors on human erythrocytes and hepatocyte membrane

International Journal of Medical Microbiology, 2023
Plasmodium falciparum-related malaria represents a serious worldwide public health problem due to its high mortality rates. P. falciparum expresses rhoptry neck protein 4 (PfRON4) in merozoite and sporozoite rhoptries, it participates in tight junction ...
Fredy A. Pulido-Quevedo, Gabriela Arévalo-Pinzón, Jeimmy J. Castañeda-Ramírez, Adriana Barreto-Santamaría, Manuel E. Patarroyo, Manuel A. Patarroyo   +5 more
doaj   +1 more source