Results 11 to 20 of about 373,653 (310)

Significant developments in biochemistry, urinalysis, and ligand assays.

Clinical laboratory science : journal of the American Society for Medical Technology, 1999
Łukasz Kasper
openaire   +2 more sources

Detection of the Atherosclerotic PCSK9 gene Inhibitors Through in silico Method to Improve Targeted Therapy

Biology, Medicine & Natural Product Chemistry, 2022
The PCSK9 is one of the most important marks for the evolution of therapeutic agents for atherosclerosis because its interaction with low-density lipoprotein receptors causes atherosclerosis.
Sabarinathan Sethuramalingam, Revathy Leena Ravi, Janet Rani Rajiah   +2 more
doaj   +1 more source

Resonance Raman Spectroscopy Reveals that Substrate Structure Selectively Impacts the Heme-Bound Diatomic Ligands of CYP17 [PDF]

, 2013
An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids.
Gregory, Michael C., Kincaid, James R., Mak, Piotr J., Sligar, Stephen G.   +3 more
core   +2 more sources

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]

, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris, Cascio, Duilio, Eisenberg, David S, Esswein, Shannon R, Ly, Alan T, Phillips, Martin L, Salwinski, Lukasz, Sawaya, Michael R   +7 more
core   +1 more source

Diagnostic and prognostic significance of cell death markers in patients with cirrhosis and acute decompensation

PLoS ONE, 2022
Background The transition from compensated to decompensated liver cirrhosis is a hallmark of disease progression, however, reliable predictors to assess the risk of decompensation in individual patients from routine diagnostics are lacking.
Philipp Stoffers, Sabrina Guckenbiehl, Martin Walter Welker, Stefan Zeuzem, Christian Markus Lange, Jonel Trebicka, Eva Herrmann, Christoph Welsch   +7 more
doaj   +2 more sources

Matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding

Neural Regeneration Research, 2015
Both matrix biochemistry and neurotrophic factors are known to modulate neurite outgrowth and pathfinding however, the interplay between these two factors is less studied.
Christopher M Madl, Sarah C Heilshorn
doaj   +1 more source

Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation [PDF]

, 2019
Human ileal bile acid-binding protein (hI-BABP) has a key role in the intracellular transport of bile salts. To explore the role of histidine protonation in the binding process, the pH-dependence of bile salt binding and internal dynamics in hI-BABP was ...
Egyed, Orsolya, Horváth, Gergő, Kardos, József, Kovács, Mihály, Micsonai, András, Tang, Changguo, Toke, Orsolya   +6 more
core   +4 more sources

Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins

Frontiers in Neuroscience, 2020
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems.
Thao N. T. Ho, Nikita Abraham, Richard J. Lewis   +2 more
doaj   +1 more source

Plasmodium falciparum rhoptry neck protein 4 has conserved regions mediating interactions with receptors on human erythrocytes and hepatocyte membrane

International Journal of Medical Microbiology, 2023
Plasmodium falciparum-related malaria represents a serious worldwide public health problem due to its high mortality rates. P. falciparum expresses rhoptry neck protein 4 (PfRON4) in merozoite and sporozoite rhoptries, it participates in tight junction ...
Fredy A. Pulido-Quevedo, Gabriela Arévalo-Pinzón, Jeimmy J. Castañeda-Ramírez, Adriana Barreto-Santamaría, Manuel E. Patarroyo, Manuel A. Patarroyo   +5 more
doaj   +1 more source

ABS–Scan: In silico alanine scanning mutagenesis for binding site residues in protein–ligand complex [v2; ref status: indexed, http://f1000r.es/4sf]

F1000Research, 2014
Most physiological processes in living systems are fundamentally regulated by protein–ligand interactions. Understanding the process of ligand recognition by proteins is a vital activity in molecular biology and biochemistry.
Praveen Anand, Deepesh Nagarajan, Sumanta Mukherjee, Nagasuma Chandra   +3 more
doaj   +1 more source