Results 131 to 140 of about 1,156,300 (324)

Evidencing the role of a conserved polar signaling channel in the activation mechanism of the μ-opioid receptor. [PDF]

Comput Struct Biotechnol J
Sarkar A, Dvorácskó S, Lipinszki Z, Mitra A, Harmati M, Buzás K, Borics A.   +6 more
europepmc   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

Binding Free Energy Calculations Based on the Path Collective Variable along a String Pathway. [PDF]

J Phys Chem B
Ghidini A, Cavalli A, Roux B.
europepmc   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

In silico analysis to explore the therapeutic potential of propolis-derived small molecules as matriptase inhibitors to suppress breast cancer growth and metastasis. [PDF]

PLoS One
Azmi MB, Yu H, Sohail A, Asif U, Ahmed SDH, Qureshi SA, Abdalla M.   +6 more
europepmc   +1 more source

Copper‐based Materials for Photo and Electrocatalytic Process: Advancing Renewable Energy and Environmental Applications

Advanced Functional Materials, EarlyView.
Cu‐based catalysts as a cornerstone in advancing sustainable energy technologies are fully reviewed in this manuscript, highlighting their potential in photo‐ and electrocatalysis. It includes metallic copper, copper oxides, copper sulfides, copper halide perovskites, copper‐based metal–organic frameworks (MOFs), and covalent organic frameworks (COFs),
Jéssica C. de Almeida, Yanjie Wang, Thais A. Rodrigues, Paulo H. H. Nunes, Vagner R. de Mendonça, Paulo H. E. Falsetti, Leticia V. Savazi, Tao He, Alexandra V. Bardakova, Aida V. Rudakova, Jie Tian, Alexei V. Emeline, Osmando F. Lopes, Antonio Otavio T. Patrocínio, Jia Hong Pan, Caue Ribeiro, Detlef W. Bahnemann   +16 more
wiley   +1 more source

Phytochemical profiling, biological potential and In Silico identification of anticancerous compound from Pakistani pomegranate Peel. [PDF]

Sci Rep
Badshah SM, Sultana N, Al-Rawi MBA, Tariq Z, Lin KS, Hussain A, Syed W, Ahmed D, Hussain J, Khan B, Rehman FU.   +10 more
europepmc   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Defect‐Induced Selectivity Modulation Using Copper Triazole Molecular Frameworks for Electrochemical CO2 Reduction

Advanced Functional Materials, EarlyView.
A Cu‐triazole and D‐Cu‐triazole MOF is studied for eCO2RR. After introducing open metal sites and reducing the particle size through a competitive coordination strategy with N,N‐diethylformamide, the defects significantly enhance and alter the catalytic properties with increased selectivity for C2+ products. Abstract Metal–organic frameworks (MOFs) are
Anirudha Shekhawat, Debanjan Das, Ridha Zerdoumi, Muhammad Adib Abdillah Mahbub, Bashir Eid, Shubhadeep Chandra, Sabine Seisel, Wolfgang Schuhmann   +7 more
wiley   +1 more source

Genetic and computational analysis of AKR1C4 gene rs17134592 polymorphism in breast cancer among the Bangladeshi population. [PDF]

Sci Rep
Shaon MA, Ansari F, Mahmud Z, Tamanna S, Al Saba A, Sikder R, Howlader T, Howlader MZH.   +7 more
europepmc   +1 more source