The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar+6 more
wiley +1 more source
Predicting Protein Function in the AI and Big Data Era. [PDF]
Percudani R, De Rito C.
europepmc +1 more source
Zr‐Fe MOF@Ribociclib@Herceptin (ZFRH) efficiently targets/kills Human Epidermal Growth Factor Receptor 2/Estrogen Receptor‐positive (HER2/ER+) breast cancer cells. It combats tumors by: 1) Elevating ROS, altering redox balance; 2) Inhibiting transcription; 3) Inducing pyroptosis.
Hongkun Miao+8 more
wiley +1 more source
Investigation of the inhibitory potential of secondary metabolites isolated from Fernandoa adenophylla against Beta-glucuronidase via molecular docking and molecular dynamics simulation studies. [PDF]
Rauf A+11 more
europepmc +1 more source
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu+7 more
wiley +1 more source
Proton and Metal Dication Affinities of Tetracyclic Imidazo[4,5-<i>b</i>]Pyridine-Based Molecules: Insights from Mass Spectrometry and DFT Analysis. [PDF]
Vrban L+6 more
europepmc +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth+2 more
wiley +1 more source
A Geranylated Natural Product Simamycin Disrupts the Allosteric Catalysis of tRNA-2-selenouridine Synthase SelU. [PDF]
Dansereau SJ+6 more
europepmc +1 more source
Toward the 3rd Generation of Smart Farming: Materials, Devices, and Systems for E‐Plant Technologies
This review explores the latest developments in e‐plant technologies, which are revolutionizing smart farming by enabling real‐time monitoring of plant and environmental conditions. It covers the design, applications, and systems of e‐plant devices, detailing how they integrate data analytics to optimize agricultural practices, enhance crop yields, and
Daegun Kim+5 more
wiley +1 more source
Predicting Affinity Through Homology (PATH): Interpretable binding affinity prediction with persistent homology. [PDF]
Long Y, Donald BR.
europepmc +1 more source