Results 171 to 180 of about 1,373,014 (370)

Structural and biochemical determinants of ligand binding by the c-di-GMP riboswitch .

Biochemistry, 2010
Kathryn D. Smith, S. V. Lipchock, Alison L. Livingston, Carly A. Shanahan, S. Strobel   +4 more
semanticscholar   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Stereochemistry and Charged State Influence Effector Outcomes of d-2-Hydroxyglutarate Dehydrogenase Ligands. [PDF]

Biochemistry
Quaye JA, Gadda G.
europepmc   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Photoactivatable Ru(ii) polypyridyl complexes as dual action modulators of amyloid-beta peptide aggregation and Cu redox cycling. [PDF]

Chem Sci
Leech G, Acosta AL, Mahato S, Barrett PC, Hodges RO, McFarland SA, Storr T.   +6 more
europepmc   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Evaluating the pentapharmacological potency of otamixaban against lung cancer CDK2, transferase, oxidoreductase and signalling proteins. [PDF]

PLoS One
Baeissa HM, Bakhsh T, Shakoori AM, Sindi G, Zaki RM, Kamal MA, Alsufyani HA, Habib AH, Ishaq A Khayyat A, Rafeeq M, Jairajpuri DS.   +10 more
europepmc   +1 more source

Bicontinuous Microarchitected Scaffolds Provide Topographic Cues That Govern Neuronal Behavior and Maturation

Advanced Functional Materials, EarlyView.
A scalable biomimetic platform transforms bioinert poly(ethylene glycol) diacrylate into neuroinstructive matrices via integrating solvent transfer‐induced phase separation, microfluidics, and 3D bioprinting. Bicontinuous, hyperbolically curved microporous networks embedded within a fibrous construct elicit rapid adhesion, robust proliferation, and ...
Prince D. Okoro, Kevin Dalsania, Shiril B. Iragavarapu, Benjamin Dela Cruz, Aihik Banerjee, Merve Basaranbilek, Martin F. Haase, Bahman Anvari, Iman Noshadi   +8 more
wiley   +1 more source

Cryo-EM ligand building using AlphaFold3-like model and molecular dynamics. [PDF]

PLoS Comput Biol
Haloi N, Howard RJ, Lindahl E.
europepmc   +1 more source

All‐Inorganic InP/ZnSe/ZnS Quantum Dots with Chalcogenidometallate Ligands for Biosolar Catalysis

Advanced Functional Materials, EarlyView.
Intrinsic charge transfer limitations in core/shell QDs are addressed through a ligand‐induced band offset engineering (LBOE) strategy utilizing metal chalcogenide complex (MCC) ligands. The MCC‐functionalized InP/ZnSe/ZnS QDs exhibited remarkably augmented hydrogen peroxide (H2O2) generation.
Jaehwan Lee, Yonghan Jo, Seongbeom Yeon, Jinha Jang, Jaeyeong Ha, Bokyeong Sohn, Hyunjin Cho, Gui‐Min Kim, Doh C. Lee, Chan Beum Park, Himchan Cho   +10 more
wiley   +1 more source