Results 191 to 200 of about 363,417 (316)

Proton and Metal Dication Affinities of Tetracyclic Imidazo[4,5-<i>b</i>]Pyridine-Based Molecules: Insights from Mass Spectrometry and DFT Analysis. [PDF]

Molecules
Vrban L, Martinac IA, Hranjec M, Pocrnić M, Galić N, Kobetić R, Vianello R.   +6 more
europepmc   +1 more source

Quantum biochemistry insights into ligand recognition at the α1A-adrenoceptor

da Costa Gomes, Luana Talinne, SALES BEZERRA, KATYANNA, Gavioli, Elaine, Ivan Nobre Oliveira, Jonas, Fulco, U. L., Silva Júnior, Edilson Dantas da   +5 more
openaire   +1 more source

Si Inhibited Osteoclastogenesis: The Role of Fe and the Fenton Reaction

Advanced Healthcare Materials, EarlyView.
Silicate (Si) inhibition of osteoclastogenesis, is mediated by Fe. Si chemical interactions with Fe inhibit the Fenton reaction and intercellular ROS availability. This reduction in ROS availability inhibits osteoclastogenesis. The addition of Fe, in Si‐inhibited osteoclast cultures, restores the Fenton reaction, and osteoclastogenesis.
Yutong Li, Adriana‐Monica Radu, Azadeh Rezaei, Joel Turner, Kaveh Shakib, Akiko Obata, Toshihiro Kasuga, Gavin Jell   +7 more
wiley   +1 more source

Uvarinol and Dichamanetin Derived from <i>Uvaria chamae</i> as Potential Dual-Site Inhibitors Against PBP2a in Methicillin Resistant <i>Staphylococcus aureus</i>: An In Silico Study. [PDF]

Pharmaceuticals (Basel)
Agbebi EA, Adeyemi SO, Adewale AI, Ajofoyinbo OS, Olugbogi EA, Oyinloye OM, Anuoluwa IA, Agbebi TO, Ajiboye BO, Oyinloye BE.   +9 more
europepmc   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Predicting Affinity Through Homology (PATH): Interpretable binding affinity prediction with persistent homology. [PDF]

PLoS Comput Biol
Long Y, Donald BR.
europepmc   +1 more source

Ultra‐Tiny Gelatin Nanoparticles‐Assisted 3D Stem Cell Spheroids for Engineering Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
GNPs effectively guide the formation of structurally compact and functionally enhanced stem cell spheroids. This GNP‐assisted 3D culture system improves cell–cell and cell‐ECM interactions, leading to superior viability and complexity. Time‐dependent regenerative potential is demonstrated in both bone and skin defects, positioning GNP‐spheroids as a ...
Dream Kim, Woochan Kim, Harshita Sharma, Shinyull Lee, Chaeyeon Park, Sunho Park, Chan Yeong Heo, Jangho Kim   +7 more
wiley   +1 more source

Identification of Novel Compounds That Bind to the HGF β-Chain In Silico, Verification by Molecular Mechanics and Quantum Mechanics, and Validation of Their HGF Inhibitory Activity In Vitro. [PDF]

Molecules
Suzuki K, Inoue K, Namiguchi R, Morita S, Hayakawa S, Yokota M, Sakai K, Matsumoto K, Aoki S.   +8 more
europepmc   +1 more source

Engineering Extracellular Microenvironments: The Impact of Fibrous Materials on Cell Behavior

Advanced Healthcare Materials, EarlyView.
Fibrous structures are key elements of the native extracellular matrix and crucial for directing cell behavior. This review discusses how fiber properties such as composition, diameter, and alignment affect cell responses in 2D and 3D systems. Strategies for integrating fibrous cues into engineered tissues are highlighted, and future directions for ...
Zan Lamberger, Gregor Lang
wiley   +1 more source

Insights into the structural dynamics of the secretin family (class B1) G protein-coupled receptors. [PDF]

J Biol Chem
Liu T, Naidoo NR, Agyemang E, Lamichhane R.   +3 more
europepmc   +1 more source