Results 21 to 30 of about 1,156,300 (324)

Preliminary investigation of deoxyoligonucleotide binding to ribonuclease A using mass spectrometry: An attempt to develop a lab experience for undergraduates [version 2; referees: 2 approved]

F1000Research, 2018
Deoxyoligonucleotide binding to bovine pancreatic ribonuclease A (RNase A) was investigated using electrospray ionization ion-trap mass spectrometry (ESI-IT-MS). Deoxyoligonucleotides included CCCCC (dC5) and CCACC (dC2AC2).
Daniel D. Clark
doaj   +1 more source

Conformational selection is a dominant mechanism of ligand binding.

Biochemistry, 2013
Molecular recognition in biological macromolecules is achieved by binding interactions coupled to conformational transitions that precede or follow the binding step, two limiting mechanisms known as conformational selection and induced fit, respectively.
Austin D. Vogt, E. Di Cera
semanticscholar   +1 more source

Preliminary investigation of deoxyoligonucleotide binding to ribonuclease A using mass spectrometry: An attempt to develop a lab experience for undergraduates [version 1; referees: 2 approved]

F1000Research, 2018
Deoxyoligonucleotide binding to bovine pancreatic ribonuclease A (RNase A) was investigated using electrospray ionization ion-trap mass spectrometry (ESI-IT-MS). Deoxyoligonucleotides included CCCCC (dC5) and CCACC (dC2AC2).
Daniel D. Clark
doaj   +1 more source

From Bench to Bedside: Patient-Oriented Radiopharmaceutical Development in Nuclear Medicine Based on the Example of [⁸⁹Zr]Zr-PSMA-DFO

Molecules, 2023
The interdisciplinary possibilities inherent in nuclear medicine offer an opportunity for the patient-centered development of radioactive pharmaceuticals based on specific research questions.
Klaus Schomäcker, Felix Dietlein, Sergio Muñoz Vázquez, Feodor Braun, Thomas Fischer, Philipp Krapf, Alexander Drzezga, Markus Dietlein   +7 more
doaj   +1 more source

Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

eLife, 2021
Shprintzen–Goldberg syndrome (SGS) is a multisystemic connective tissue disorder, with considerable clinical overlap with Marfan and Loeys–Dietz syndromes. These syndromes have commonly been associated with enhanced TGF-β signaling.
Ilaria Gori, Roger George, Andrew G Purkiss, Stephanie Strohbuecker, Rebecca A Randall, Roksana Ogrodowicz, Virginie Carmignac, Laurence Faivre, Dhira Joshi, Svend Kjær, Caroline S Hill   +10 more
doaj   +1 more source

Site-Differentiated Iron–Sulfur Cluster Ligation Affects Flavin-Based Electron Bifurcation Activity

Metabolites, 2022
Electron bifurcation is an elegant mechanism of biological energy conversion that effectively couples three different physiologically relevant substrates.
Courtney E. Wise, Anastasia E. Ledinina, Carolyn E. Lubner   +2 more
doaj   +1 more source

The selectivity of Vibrio cholerae H-NOX for gaseous ligands follows the "sliding scale rule" hypothesis. Ligand interactions with both ferrous and ferric Vc H-NOX.

Biochemistry, 2013
Vc H-NOX (or VCA0720) is an H-NOX (heme-nitric oxide and oxygen binding) protein from facultative aerobic bacterium Vibrio cholerae. It shares significant sequence homology with soluble guanylyl cyclase (sGC), a NO sensor protein commonly found in ...
Gang Wu, Wen Liu, V. Berka, A. Tsai
semanticscholar   +1 more source

Structural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist binding.

PLoS ONE, 2014
To predict structural and energetic effects of point mutations on ligand binding is of considerable interest in biochemistry and pharmacology. This is not only useful in connection with site-directed mutagenesis experiments, but could also allow ...
Henrik Keränen, Hugo Gutiérrez-de-Terán, Johan Åqvist   +2 more
doaj   +1 more source

Significant developments in biochemistry, urinalysis, and ligand assays.

Clinical laboratory science : journal of the American Society for Medical Technology, 1999
Łukasz Kasper
openalex   +2 more sources

Nuclear receptor coactivators: structural and functional biochemistry.

Biochemistry, 2011
Transcription of eukaryotic cell is a multistep process tightly controlled by concerted action of macromolecules. Nuclear receptors are ligand-activated sequence-specific transcription factors that bind DNA and activate (or repress) transcription of ...
Yaroslava A. Bulynko, B. O’Malley
semanticscholar   +1 more source