Results 21 to 30 of about 1,177,346 (315)

The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel

Nature Communications, 2018
Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion ...
Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang Nörenberg, Heike Franke, Flóra Gölöncsér, Beáta Sperlágh, Anke Dopychai, Ralf Hausmann, Günther Schmalzing, Patrizia Rubini, Peter Illes   +14 more
doaj   +1 more source

Preliminary investigation of deoxyoligonucleotide binding to ribonuclease A using mass spectrometry: An attempt to develop a lab experience for undergraduates [version 2; referees: 2 approved]

F1000Research, 2018
Deoxyoligonucleotide binding to bovine pancreatic ribonuclease A (RNase A) was investigated using electrospray ionization ion-trap mass spectrometry (ESI-IT-MS). Deoxyoligonucleotides included CCCCC (dC5) and CCACC (dC2AC2).
Daniel D. Clark
doaj   +1 more source

Preliminary investigation of deoxyoligonucleotide binding to ribonuclease A using mass spectrometry: An attempt to develop a lab experience for undergraduates [version 1; referees: 2 approved]

F1000Research, 2018
Deoxyoligonucleotide binding to bovine pancreatic ribonuclease A (RNase A) was investigated using electrospray ionization ion-trap mass spectrometry (ESI-IT-MS). Deoxyoligonucleotides included CCCCC (dC5) and CCACC (dC2AC2).
Daniel D. Clark
doaj   +1 more source

Pressure, motion, and conformational entropy in molecular recognition by proteins

Biophysical Reports, 2023
The thermodynamics of molecular recognition by proteins is a central determinant of complex biochemistry. For over a half-century, detailed cryogenic structures have provided deep insight into the energetic contributions to ligand binding by proteins ...
José A. Caro, Kathleen G. Valentine, Taylor R. Cole, A. Joshua Wand   +3 more
doaj   +1 more source

From Bench to Bedside: Patient-Oriented Radiopharmaceutical Development in Nuclear Medicine Based on the Example of [⁸⁹Zr]Zr-PSMA-DFO

Molecules, 2023
The interdisciplinary possibilities inherent in nuclear medicine offer an opportunity for the patient-centered development of radioactive pharmaceuticals based on specific research questions.
Klaus Schomäcker, Felix Dietlein, Sergio Muñoz Vázquez, Feodor Braun, Thomas Fischer, Philipp Krapf, Alexander Drzezga, Markus Dietlein   +7 more
doaj   +1 more source

Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

eLife, 2021
Shprintzen–Goldberg syndrome (SGS) is a multisystemic connective tissue disorder, with considerable clinical overlap with Marfan and Loeys–Dietz syndromes. These syndromes have commonly been associated with enhanced TGF-β signaling.
Ilaria Gori, Roger George, Andrew G Purkiss, Stephanie Strohbuecker, Rebecca A Randall, Roksana Ogrodowicz, Virginie Carmignac, Laurence Faivre, Dhira Joshi, Svend Kjær, Caroline S Hill   +10 more
doaj   +1 more source

High-Resolution Crystal Structure of Arabidopsis FLOWERING LOCUS T Illuminates Its Phospholipid-Binding Site in Flowering

iScience, 2019
Summary: Arabidopsis FLOWERING LOCUS T (FT) is a pivotal component of florigen, a long-range mobile flowering signal. Here, we determined the 1.0 Å-resolution crystal structure of FT, a significantly higher-resolution crystal structure of FT than ...
Yuki Nakamura, Ying-Chen Lin, Satoshi Watanabe, Yu-chi Liu, Kentaro Katsuyama, Kazue Kanehara, Kenji Inaba   +6 more
doaj   +1 more source

Optimizing ligand-receptor binding thermodynamics and kinetics: The role of Terahertz wave modulation in molecular recognition

Fundamental Research
Precision control over ligand-receptor recognition is critical in biochemistry and pharmacology. Traditional methods that alter reaction environments have limitations in fine-tuning the thermodynamic and kinetic aspects of biochemical reactions within ...
Yibo Wang, Cong Zhang, Mingqi Li, Xiaohui Wang   +3 more
doaj   +1 more source

Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil

Molecules, 2020
Plant seeds have been found to contain bioactive compounds that have potential nutraceutical benefits. Guava seeds (Psidium guajava) are by-products in the beverage and juice industry; however, they can be utilized for a variety of commercial purposes ...
Adchara Prommaban, Niramon Utama-ang, Anan Chaikitwattana, Chairat Uthaipibull, John B. Porter, Somdet Srichairatanakool   +5 more
doaj   +1 more source

Site-Differentiated Iron–Sulfur Cluster Ligation Affects Flavin-Based Electron Bifurcation Activity

Metabolites, 2022
Electron bifurcation is an elegant mechanism of biological energy conversion that effectively couples three different physiologically relevant substrates.
Courtney E. Wise, Anastasia E. Ledinina, Carolyn E. Lubner   +2 more
doaj   +1 more source