Results 301 to 310 of about 1,177,346 (315)

The role of ligand efficiency metrics in drug discovery

Nature Reviews Drug Discovery, 2014
Andrew L Hopkins, Paul D Leeson, Charles H Reynolds   +2 more
exaly  

Benzodiazepine recognition site ligands: biochemistry and pharmacology.

, 1983
G. Biggio, Erminio Costa
openalex  

Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor.

Biochemistry, 1997
P. Doesburg, C. Kuil, C. Berrevoets, K. Steketee, P. Faber, E. Mulder, A. Brinkmann, J. Trapman   +7 more
semanticscholar   +1 more source

Clostridium thermocellum Xyn10B carbohydrate-binding module 22-2: the role of conserved amino acids in ligand binding.

Biochemistry, 2001
H. Xie, H. Gilbert, S. Charnock, G. Davies, M. Williamson, P. Simpson, S. Raghothama, C. Fontes, F. Dias, L. Ferreira, D. N. Bolam   +10 more
semanticscholar   +1 more source

Targeting Apoptosis Pathways in Cancer Therapy

Ca-A Cancer Journal for Clinicians, 2005
exaly  

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

Nature Reviews Drug Discovery, 2015
Madduri Srinivasarao, Philip S Low
exaly  

Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions.

Biochemistry, 2005
J. Kavanaugh, P. Rogers, A. Arnone
semanticscholar   +1 more source

Crystal structures of the family 9 carbohydrate-binding module from Thermotoga maritima xylanase 10A in native and ligand-bound forms.

Biochemistry, 2001
V. Notenboom, A. Boraston, D. Kilburn, D. Rose   +3 more
semanticscholar   +1 more source

Ligand-targeted therapeutics in anticancer therapy

Nature Reviews Cancer, 2002
Theresa M Allen
exaly  

Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.

Biochemistry, 1994
C. Bystroff, J. Kraut
semanticscholar   +1 more source