Results 41 to 50 of about 379,006 (309)

Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of ascaris reveals a novel fold and two discrete lipid-binding sites [PDF]

, 2011
Parasitic nematode worms cause serious health problems in humans and other animals. They can induce allergic-type immune responses, which can be harmful but may at the same time protect against the infections. Allergens are proteins that trigger allergic
A Cooper, A Garofalo, Alan Cooper, Alejandro Buschiazzo, AT Brunger, BB Kragelund, Brian O. Smith, BS Mei, C Britton, C Lucke, C McSharry, CB Poole, CB Poole, CB Poole, DS Wishart, DS Wishart, Dušan Uhrín, ED Laue, GJ Kleywegt, Graeme Ball, GW Han, HJ Sass, HJ Spence, HS Lee, I Vercauteren, J Culpepper, J Dundas, J Moore, J Plenefisch, JA Rothnagel, JC Kader, JD Turner, JP Linge, JP Linge, JR Allison, JT Jones, JT Vivian, KH Mok, Krystyna Bromek, L Holm, L Kuang, L McDermott, LA Tomlinson, LE Kay, M Blaxter, M Furuhashi, M Nilges, M Ottiger, M Piotto, M Zweckstetter, M Zweckstetter, Malcolm W. Kennedy, MR Hansen, MS Cheung, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, N Acevedo, N Tjandra, NA Farrow, NAG Meenan, NAG Meenan, Nicola A. G. Meenan, P Ovaere, P Permi, P Permi, PJ Kraulis, R Jordanova, R Jordanova, RA Laskowski, RB Presland, RID Wakefield, RM Maizels, RW Alston, S Basavaraju, S Bennuru, S Curry, S Tweedie, WA Paxton, WF Vranken, Y Xia, YP Tong   +87 more
core   +7 more sources

Structural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist binding.

PLoS ONE, 2014
To predict structural and energetic effects of point mutations on ligand binding is of considerable interest in biochemistry and pharmacology. This is not only useful in connection with site-directed mutagenesis experiments, but could also allow ...
Henrik Keränen, Hugo Gutiérrez-de-Terán, Johan Åqvist   +2 more
doaj   +1 more source

A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources

Recent Advances in Optical DNA Biosensors Technology

CHIMIA, 2005
Recent advances in nucleic acids-based biosensors have led to the development of DNA biosensors for DNA hybridisation detection and for nucleic acid–ligand binding studies.
Bambang Kuswandi, Sara Tombelli, Giovanna Marazza, Marco Mascini   +3 more
doaj   +1 more source

Theoretical Evaluation of Novel Thermolysin Inhibitors from Bacillus thermoproteolyticus. Possible Antibacterial Agents

Molecules, 2021
The search for new antibacterial agents that could decrease bacterial resistance is a subject in continuous development. Gram-negative and Gram-positive bacteria possess a group of metalloproteins belonging to the MEROPS peptidase (M4) family, which is ...
Emilio Lamazares, Desmond MacLeod-Carey, Fernando P. Miranda, Karel Mena-Ulecia   +3 more
doaj   +1 more source

Use of a distant reporter group as evidence for a conformational change in a sensory receptor [PDF]

, 1977
A highly sensitive method for demonstrating ligand-induced conformational changes in protein molecules in solution is described. The method utilizes an environmentally sensitive reporter group that is known to be distant from the active site.
Hartig, P. R., Koshland, D. E., Jr., Zukin, R. S.   +2 more
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

4-[(E)-2-(1-Pyrenyl)Vinyl]Pyridine Complexes: How to Modulate the Toxicity of Heavy Metal Ions to Target Microbial Infections

Molecules
Pyrene derivatives are regularly proposed for use in biochemistry as dyes due to their photochemical characteristics. Their antibacterial properties are, however, much less well understood. New complexes based on 4-[(E)-2-(1-pyrenyl)vinyl]pyridine (PyPe)
Justine V. Schwarte, Aurélien Crochet, Katharina M. Fromm   +2 more
doaj   +1 more source

Advances in thiosemicarbazone metal complexes as anti-lung cancer agents

Frontiers in Pharmacology, 2022
The great success of cisplatin as a chemotherapeutic agent considerably increased research efforts in inorganic biochemistry to identify more metallic drugs having the potential of treating lung cancer.
Xian-Guang Bai, Yunyun Zheng, Jinxu Qi
doaj   +1 more source

Molecular Requirements for Ethanol Differential Allosteric Modulation of Ligand-Gated Ion Channels Based on Selective G Beta Gamma Modulation [PDF]

, 2010
It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure.
Aguayo, Luis G, Avila, Ariel, Figueroa, Maximiliano, Guzman, Leonardo, Moraga-Cid, Gustavo, Peoples, Robert W., Yevenes, Gonzalo E   +6 more
core   +1 more source