Results 51 to 60 of about 1,156,300 (324)

Detection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis.

open access: yesBiochemistry, 2009
The aryl hydrocarbon receptor (AhR) is a ligand-dependent, basic helix-loop-helix Per-Arnt-Sim (PAS)-containing transcription factor that can bind and be activated by structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8 ...
A. Pandini   +5 more
semanticscholar   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Factors affecting light energy transfer in some samarium complexes

open access: yesInternational Journal of Photoenergy, 2005
The photophysical properties of samarium ion in presence of 7-Acetoxy Coumarin 3-Carboxylic acid (ACC) or 1-(4-methoxyphenyl) 3-(4-t-butyl phenyl) 1,3-propandione (MBPK), which act as antenna of near-UV radiation, are studied in different homogeneous ...
Esam Bakier, M. S. A. Abdel-Mottaleb
doaj   +1 more source

Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions

open access: yesBiomolecules, 2021
The 100th anniversary of Notch discovery in Drosophila has recently passed. The Notch is evolutionarily conserved from Drosophila to humans. The discovery of human-specific Notch genes has led to a better understanding of Notch signaling in development ...
Wataru Saiki   +3 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Probing the Bioinorganic Chemistry of Cu(I) with 111Ag Perturbed Angular Correlation (PAC) Spectroscopy

open access: yesInorganics, 2023
The two most common oxidation states of copper in biochemistry are Cu(II) and Cu(I), and while Cu(II) lends itself to spectroscopic interrogation, Cu(I) is silent in most techniques.
Victoria Karner   +2 more
doaj   +1 more source

Poster Presentations [PDF]

open access: yesThe FEBS Journal, 2006
Thromboxane A2 induces platelet aggregation and constriction of vascular and bronchial smooth muscle through the interaction with a G protein-coupled receptor that exists as two alternatively splice variants, termed TPa and TPb with different C-terminal cytoplasmic tails.
E. Scotti   +14 more
openaire   +46 more sources

Two Decades of Evolution of Our Understanding of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel

open access: yesLife, 2021
The transient receptor potential melastatin (TRPM) family belongs to the superfamily of TRP ion channels. It consists of eight family members that are involved in a plethora of cellular functions.
Andras Szollosi
doaj   +1 more source

Exploring molecular mechanisms of ligand recognition by opioid receptors with metadynamics.

open access: yesBiochemistry, 2009
Opioid receptors are G protein-coupled receptors (GPCRs) of utmost significance in the development of potent analgesic drugs for the treatment of severe pain.
D. Provasi, A. Bortolato, M. Filizola
semanticscholar   +1 more source

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