Results 51 to 60 of about 369,161 (297)

Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of ascaris reveals a novel fold and two discrete lipid-binding sites [PDF]

, 2011
Parasitic nematode worms cause serious health problems in humans and other animals. They can induce allergic-type immune responses, which can be harmful but may at the same time protect against the infections. Allergens are proteins that trigger allergic
A Cooper, A Garofalo, Alan Cooper, Alejandro Buschiazzo, AT Brunger, BB Kragelund, Brian O. Smith, BS Mei, C Britton, C Lucke, C McSharry, CB Poole, CB Poole, CB Poole, DS Wishart, DS Wishart, Dušan Uhrín, ED Laue, GJ Kleywegt, Graeme Ball, GW Han, HJ Sass, HJ Spence, HS Lee, I Vercauteren, J Culpepper, J Dundas, J Moore, J Plenefisch, JA Rothnagel, JC Kader, JD Turner, JP Linge, JP Linge, JR Allison, JT Jones, JT Vivian, KH Mok, Krystyna Bromek, L Holm, L Kuang, L McDermott, LA Tomlinson, LE Kay, M Blaxter, M Furuhashi, M Nilges, M Ottiger, M Piotto, M Zweckstetter, M Zweckstetter, Malcolm W. Kennedy, MR Hansen, MS Cheung, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, MW Kennedy, N Acevedo, N Tjandra, NA Farrow, NAG Meenan, NAG Meenan, Nicola A. G. Meenan, P Ovaere, P Permi, P Permi, PJ Kraulis, R Jordanova, R Jordanova, RA Laskowski, RB Presland, RID Wakefield, RM Maizels, RW Alston, S Basavaraju, S Bennuru, S Curry, S Tweedie, WA Paxton, WF Vranken, Y Xia, YP Tong   +87 more
core   +7 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Application of CoLD-CoP to Detecting Competitively and Cooperatively Binding Ligands

Biomolecules
NMR utilization in fragment-based drug discovery requires techniques to detect weakly binding fragments and to subsequently identify cooperatively binding fragments. Such cooperatively binding fragments can then be optimized or linked in order to develop
Shiva V. Patnala, Roberto Robles, David A. Snyder   +2 more
doaj   +1 more source

Current Applications and Future Perspectives of CRISPR-Cas9 for the Treatment of Lung Cancer

Biologics: Targets & Therapy, 2021
Markeshaw Tiruneh G/Medhin,1 Endeshaw Chekol Abebe,2 Tekeba Sisay,3 Nega Berhane,3 Tesfahun Bekele Snr,1 Tadesse Asmamaw Dejenie1 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar ...
Tiruneh G/Medhin M, Chekol Abebe E, Sisay T, Berhane N, Bekele Snr T, Asmamaw Dejenie T   +5 more
doaj  

Gain–of–Function Genetic Models to Study FSH Action

Frontiers in Endocrinology, 2019
Follicle–stimulating hormone (FSH) is a pituitary-derived gonadotropin that plays key roles in male and female reproduction. The physiology and biochemistry of FSH have been extensively studied for many years.
Rosemary McDonald, Rosemary McDonald, Carolyn Sadler, T. Rajendra Kumar, T. Rajendra Kumar, T. Rajendra Kumar   +5 more
doaj   +1 more source

A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations

Antioxidants, 2022
Cytoglobin is a hexacoordinate hemoglobin with physiological roles that are not clearly understood. Previously proposed physiological functions include nitric oxide regulation, oxygen sensing, or/and protection against oxidative stress under hypoxic ...
John Ukeri, Michael T. Wilson, Brandon J. Reeder   +2 more
doaj   +1 more source

X-ray Crystallographic Characterization of the Co(II)-substituted Tris-bound Form of the Aminopeptidase from \u3cem\u3eAeromonas proteolytica\u3c/em\u3e [PDF]

, 2007
The X-ray crystal structure of the Co(II)-loaded form of the aminopeptidase from Aeromonas proteolytica ([CoCo(AAP)]) was solved to 2.2 Å resolution. [CoCo(AAP)] folds into an α/β globular domain with a twisted β-sheet hydrophobic core sandwiched between
Bennett, Brian, Holz, Richard C., Moulin, Aaron, Munih, Petra, Petsko, Gregory A., Ringe, Dagmar, Stamper, Carin   +6 more
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source