Results 171 to 180 of about 905,008 (316)

Short Peptoid Capping Ligands Stabilize Dispersion of Gold Nanospheres in Aqueous Solutions. [PDF]

Langmuir
Goldberg HG, Matusich IK, Petersen JM, Raman N, Hong JC, Edler G, Tanaka DK, Javed JM, Fuller AA.   +8 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

FLOWR: flow matching for structure-aware de novo, interaction- and fragment-based ligand generation. [PDF]

Nat Comput Sci
Cremer J, Irwin R, Tibo A, Janet JP, Olsson S, Clevert DA.   +5 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

<i>OncoSolidDB</i>: An Oncology-Focused Curated Database of Ligand-Target Interactions for Precision Medicine Across Major Solid Cancers. [PDF]

Cancers (Basel)
Khamessi O, Mahjoub R, Mahjoub G, Ghedira K.   +3 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Do G4 ligands induce mitochondrial dysfunction without ROS induction. [PDF]

iScience
Zhang X, Li F, Zeng S, Lian D, Cheng Q, Li L, Gao X, Wang Q, Qin Y, Du J, Li Q, Song Z, Qi Q, Granzhan A, Bombard S, Jia 贾涛 T.   +15 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Synthesis of Functional Metallosupramolecular Complexes [PDF]

This thesis describes three areas of research which involve preparation of novel pyridyl-thiazole-containing ligands and the formation of their complexes with transition metal ions.
Cox, Nicola Michelle
core  

MotifLeadDB: A Hierarchical Structural Data Set for Congeneric Ligand Binding Activity Change. [PDF]

J Chem Inf Model
Kim N, Bae B, Jung N, Seok C, Park H.
europepmc   +1 more source