Results 11 to 20 of about 1,596,891 (346)
Cells, 2021 A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan contexts, as their outermost sugar moiety. Among their functions, glycans engage complementary glycan binding proteins (lectins) to regulate cell physiology.
Anabel Gonzalez-Gil, Ronald L. Schnaar
openaire +3 more sources
Ligand‐dependent ribozymes [PDF]
WIREs RNA, 2016 The discovery of catalytic RNA (ribozymes) more than 30 years ago significantly widened the horizon of RNA‐based functions in natural systems. Similarly to the activity of protein enzymes that are often modulated by the presence of an interaction partner, some examples of naturally occurring ribozymes are influenced by ligands that can either act as ...
Felletti, Michele, Hartig, Jörg S.
openaire +3 more sources
Aryl Hydrocarbon Receptor as an Anticancer Target: An Overview of Ten Years Odyssey
Molecules, 2023 Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor belonging to the basic helix–loop–helix (bHLH)/per-Arnt-sim (PAS) superfamily, is traditionally known to mediate xenobiotic metabolism.
Hamza Hanieh +4 more
doaj +1 more source
Stereoelectronic effects on the binding of neutral Lewis bases to CdSe nanocrystals [PDF]
, 2018 Using P-31 nuclear magnetic resonance (NMR) spectroscopy, we monitor the competition between tri-nbutylphosphine (Bu3P) and various amine and phosphine ligands for the surface of chloride terminated CdSe nanocrystals.
Anderson, Nicholas C +4 more
core +2 more sources
Advances on Mrgprs itch receptors and their ligands
Pifu-xingbing zhenliaoxue zazhi, 2023 Although histamine is an important physiologically active substance in pruritus,antihistamine drugs can only relieve a small proportion of symptoms in chronic pruritus.
Jing HU, Zhijian CAO
doaj +1 more source
A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins [PDF]
, 2017 Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation.
Cavalcanti-Adam, Elisabetta Ada +12 more
core +2 more sources
The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs [PDF]
, 2013 G protein coupled receptors (GPCRs) are the most historically successful therapeutic targets. Despite this success there are many important aspects of GPCR pharmacology and function that have yet to be exploited to their full therapeutic potential.
Hudson, Brian D. +2 more
core +1 more source
TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death [PDF]
, 2019 Sigma-2 receptors have been implicated in both tumor proliferation and neurodegenerative diseases. Recently the sigma-2 receptor was identified as transmembrane protein 97 (TMEM97).
Hawkins, William G. +9 more
core +3 more sources
Aptamer-Based Technologies in Foodborne Pathogen Detection
Frontiers in Microbiology, 2016 Aptamers are single stranded DNA or RNA ligands, which can be selected by a method called systematic evolution of ligands by exponential enrichment (SELEX); and they can specifically recognize and bind to their targets.
Jun Teng +7 more
doaj +1 more source
CAT-Site: Predicting Protein Binding Sites Using a Convolutional Neural Network
Pharmaceutics, 2022 Identifying binding sites on the protein surface is an important part of computer-assisted drug design processes. Reliable prediction of binding sites not only assists with docking algorithms, but it can also explain the possible side-effects of a ...
Žan Hafner Petrovski +2 more
doaj +1 more source