Results 41 to 50 of about 905,008 (316)
Enhancing the photoluminescence quantum yields of blue-emitting cationic iridium(III) complexes bearing bisphosphine ligands [PDF]
, 2016 EZ-C acknowledges the University of St Andrews for financial support. We thank Johnson Matthey and Umicore AG for the gift of materials and Cihang Yu for the preparation of isopropxantphos. We thank Dr. Nail Shaveleev for the synthesis of NMS25. IDWS and
Henwood, Adam Francis +11 more
core +1 more source
New insights in the immunobiology of IL 1 family members
Frontiers in Immunology, 2013 The interleukin-1 (IL 1) family of ligands is associated with acute and chronic inflammation, and plays an essential role in the non-specific innate response to infection.
Frank Van De Veerdonk, Mihai eNetea
doaj +1 more source
Molecular mechanisms and kinetics between DNA and DNA binding ligands [PDF]
, 2005 Sischka A, Tönsing K, Eckel R, et al. Molecular mechanisms and kinetics between DNA and DNA binding ligands. Biophysical Journal. 2005;88(1):404-411.Mechanical properties of single double-stranded DNA (dsDNA) in the presence of different binding ligands ...
Anselmetti, Dario +9 more
core +2 more sources
Role of PPAR Receptor and Ligands in the Pathogenesis and Therapy of Hematologic Malignancies
Hemato, 2022 The Peroxisome proliferator-activated receptors (PPARs) play vital roles in regulating cellular differentiation, proliferation, and caspase-mediated cell death pathways. They are regarded as promising targets for anti-tumor drug development, particularly
Jian Wu, Min Zhang, Allison Faircloth
doaj +1 more source
Galanin Receptors and Ligands [PDF]
Frontiers in Endocrinology, 2012 The neuropeptide galanin was first discovered 30 years ago. Today, the galanin family consists of galanin, galanin-like peptide (GALP), galanin-message associated peptide (GMAP), and alarin and this family has been shown to be involved in a wide variety of biological and pathological functions.
Webling, Kristin E. B. +3 more
openaire +4 more sources
Design of dual ligands using excessive pharmacophore query alignment : from 7th German Conference on Chemoinformatics: 25 CIC-Workshop Goslar, Germany, 6 - 8 November 2011 [PDF]
, 2012 Dual- or multi-target ligands have gained increased attention in the past years due to several advantages, including more simple pharmacokinetic and phamarcodynamic properties compared to a combined application of several drugs.
Achenbach Janosch +26 more
core +1 more source
A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors
Frontiers in ImmunologyIntroductionNatural Killer (NK) cells play a key role in both innate and adaptive immune responses against viruses and tumor cells. Their function relies on the dynamic balance between activating and inhibitory signals, which are mediated by receptors ...
Paolo Romania +13 more
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Drug Delivery, 2022 The systemic drug has historically been preferred for the treatment of the majority of pathological conditions, particularly liver cancer. Indeed, this mode of treatment is associated with adverse reactions, toxicity, off-target accumulation, and rapid ...
Jianyong Ma +6 more
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Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
MoleculesThe rank ordering of ligands remains one of the most attractive challenges in drug discovery. While physics-based in silico binding affinity methods dominate the field, they still have problems, which largely revolve around forcefield accuracy and ...
Nupur Bansal, Ye Wang, Simone Sciabola
doaj +1 more source