Results 41 to 50 of about 1,596,891 (346)

Origin of broad polydispersion in functionalized dendrimers and its effects on cancer cell binding affinity

, 2010
Nanoparticles with multiple ligands have been proposed for use in nanomedicine. The multiple targeting ligands on each nanoparticle can bind to several locations on a cell surface facilitating both drug targeting and uptake.
Bradford G. Orr, D. Weitman, Douglas G. Mullen, G. D. Titskii, Jack N. Waddell, Leonard M. Sander, Mark M. Banaszak Holl, X. Wang   +7 more
core   +1 more source

Ligand-receptor interactions [PDF]

Reports on Progress in Physics, 1999
The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems. During the last few years, three main lines of research led to a dramatic improvement of our understanding of these important phenomena.
openaire   +3 more sources

Identification of Class I HLA T Cell Control Epitopes for West Nile Virus [PDF]

, 2013
The recent West Nile virus (WNV) outbreak in the United States underscores the importance of understanding human immune responses to this pathogen.
A Harari, A Sette, A Wahl, AC Tan, B Custer, B Shrestha, BC Braun, BEE Martina, BF Haynes, Charles R. Rinaldo, CP McMurtrey, Curtis P. McMurtrey, D Weiskopf, Diana M. Campbell, EB Bell, F Mostashari, Fredda B. Schafer, HD Hickman, HL Robinson, HL Smith, HM Jackson, J Roelse, JW Yewdell, K Eneslatt, K Prilliman, Kenneth W. Jackson, KR Prilliman, L Rodriguez Mde, M De Filette, MG Duvall, MP Busch, MR Leach, MS Diamond, MS Diamond, MS Diamond, MS Leffell, MV Larsen, N Caccamo, P Piazza, PA Wearsch, Paolo A. Piazza, PM Kloetzel, R Buchli, Rico Buchli, RS Akondy, S Kim, Saghar Kaabinejadian, Stephen R. Vernon, Steven J. Cate, T Oliphant, Tian Wang, U Seifert, WG Glass, Wilfried Bardet, William H. Hildebrand, Y Lin, Y Wang   +56 more
core   +11 more sources

A novel methodology on distributed representations of proteins using their interacting ligands

, 2018
The effective representation of proteins is a crucial task that directly affects the performance of many bioinformatics problems. Related proteins usually bind to similar ligands.
Ozkirimli, Elif, Özgür, Arzucan, Öztürk, Hakime   +2 more
core   +1 more source

Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies [PDF]

, 2010
Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised.
Aime, Aime, Aime, Aime, Aime, Ali, Andrew J. P. White, Antoni, Beeta Balali-Mood, Behnam Azad, Bottrill, Bryson, Burdinski, Caravan, Cattaneo, Chapon, Cheng, Cilliers, De Leon-Rodriguez, De Leon-Rodriguez, Delgado, Faulkner, Fields, Gabriel, Guo, Hermann, Iten, Joachim H. G. Steinke, Jonathan Martinelli, Kaneshiro, Langereis, Major, Mani, Mark F. Lythgoe, Maumela, Montgomery, Moore, Muller, New, Oliver, Patrizia Ferretti, Pratesi, Rachael Panizzo, Ramon Vilar, Roosenburg, Schlesinger, Tan, Trokowski, Villaraza, Viola-Villegas, Viswanathan, Wu, Xu, Zhang, Zucchi   +54 more
core   +1 more source

New insights in the immunobiology of IL 1 family members

Frontiers in Immunology, 2013
The interleukin-1 (IL 1) family of ligands is associated with acute and chronic inflammation, and plays an essential role in the non-specific innate response to infection.
Frank Van De Veerdonk, Mihai eNetea
doaj   +1 more source

Role of PPAR Receptor and Ligands in the Pathogenesis and Therapy of Hematologic Malignancies

Hemato, 2022
The Peroxisome proliferator-activated receptors (PPARs) play vital roles in regulating cellular differentiation, proliferation, and caspase-mediated cell death pathways. They are regarded as promising targets for anti-tumor drug development, particularly
Jian Wu, Min Zhang, Allison Faircloth
doaj   +1 more source

Novel chalcone-based fluorescent human histamine H 3 receptor ligands as pharmacological tools [PDF]

, 2012
Novel fluorescent chalcone-based ligands at human histamine H(3) receptors (hH(3)R) have been designed, synthesized, and characterized. Compounds described are non-imidazole analogs of ciproxifan with a tetralone motif.
Tomasch, Miriam, Schwed, J. Stephan, Weizel, Lilia, Stark, Holger   +3 more
core   +1 more source

A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors

Frontiers in Immunology
IntroductionNatural Killer (NK) cells play a key role in both innate and adaptive immune responses against viruses and tumor cells. Their function relies on the dynamic balance between activating and inhibitory signals, which are mediated by receptors ...
Paolo Romania, Loredana Cifaldi, Loredana Cifaldi, Paula Gragera, Valerio D’Alicandro, Matteo Caforio, Valentina Folgiero, Valeria Lucarini, Ombretta Melaiu, Ombretta Melaiu, Roberto Bei, Franco Locatelli, Franco Locatelli, Doriana Fruci   +13 more
doaj   +1 more source

Hydrogels for localized chemotherapy of liver cancer: a possible strategy for improved and safe liver cancer treatment

Drug Delivery, 2022
The systemic drug has historically been preferred for the treatment of the majority of pathological conditions, particularly liver cancer. Indeed, this mode of treatment is associated with adverse reactions, toxicity, off-target accumulation, and rapid ...
Jianyong Ma, Bingzhu Wang, Haibin Shao, Songou Zhang, Xiaozhen Chen, Feize Li, Wenqing Liang   +6 more
doaj   +1 more source