Results 61 to 70 of about 1,019,350 (256)

Well defined difluorogold( iii ) complexes supported by N-ligands

, 2018
Stable difluorogold(iii) complexes can be easily synthesized either via oxidation of N-ligated cationic Au(i) precursors using XeF or from tricationic Au(iii) precursors by displacement of the N-ligands using fluoride from economical KF.
Mohammad Al Bayer (9478709), Jason Dutton (9517505), Robert Corbo (1755928)   +2 more
core   +1 more source

Asymmetric Reactions of N-Phosphonyl/Phosphoryl Imines

Molecules, 2023
The asymmetric reactions of imines continued to attract the attention of the scientific community for decades. However, the stereoselective reactions of N-phosphonyl/phosphoryl imines remained less explored as compared to other N-substituted imines.
Devalina Ray, Suman Majee, Ram Naresh Yadav, Bimal Krishna Banik   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of Transcription

Cells, 2020
Nuclear hormone receptors are a family of transcription factors regulated by small molecules derived from the endogenous metabolism or diet. There are forty-eight nuclear hormone receptors in the human genome, twenty of which are still orphans.
Lian Jing Tao, Dong Eun Seo, Benjamin Jackson, Natalia B. Ivanova, Fabio Rinaldo Santori   +4 more
doaj   +1 more source

Structural Characterization of Alzheimer DNA Promoter Sequences from the Amyloid Precursor Gene in the Presence of Thioflavin T and Analogs

Crystals, 2022
Understanding DNA–ligand binding interactions requires ligand screening, crystallization, and structure determination. In order to obtain insights into the amyloid peptide precursor (APP) gene–Thioflavin T (ThT) interaction, single crystals of two DNA ...
Hristina Sbirkova-Dimitrova, Rusi Rusew, Nikola Kuvandjiev, Annie Heroux, Tzanko Doukov, Boris L. Shivachev   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Design of dual ligands using excessive pharmacophore query alignment : from 7th German Conference on Chemoinformatics: 25 CIC-Workshop Goslar, Germany, 6 - 8 November 2011 [PDF]

, 2012
Dual- or multi-target ligands have gained increased attention in the past years due to several advantages, including more simple pharmacokinetic and phamarcodynamic properties compared to a combined application of several drugs.
Achenbach Janosch, Klingler Franca-Maria, Daniel Moser, Franca-Maria Klingler, Ewgenij Proschak, Proschak, Ewgenij, Buscató, Estel la, Janosch Achenbach, Joanna Wisniewska, Wisniewska, Joanna Marta, la Buscató Estel, Achenbach, Janosch, Hahn, Steffen, Hofmann Bettina, Estel la Buscató, Steffen Hahn, Steinhilber Dieter, Proschak Ewgenij, Hahn Steffen, Dieter Steinhilber, Moser Daniel, Bettina Hofmann, Klingler, Franca-Maria, Hofmann, Bettina, Wisniewska Joanna, Moser, Daniel, Steinhilber, Dieter   +26 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation [PDF]

, 2020
Amphiphilic ligands are valued for their ability to facilitate organometallic reactions in the presence of water. The regioselective sulfonation of a series of commercially available biaryl monophosphines to generate amphiphilic ligands is presented ...
Jacob, Rodriguez, Heemal, Dhanjee, Stephen L., Buchwald   +2 more
core   +2 more sources