The Fibroblast Growth Factor-binding Protein (FGF-BP) and the Human Epidermal Growth Factor Receptor-2 (HER-2): functional studies on two gene products relevant in Ovarian cancer [PDF]
, 2005 Ovarialkarzinome gehören zu den weitverbreitetsten und lebensgefährlichsten gynäkologischen Tumoren mit bislang begrenzten Behandlungsmöglichkeiten.
Abuharbeid Shaker +1 more
core +1 more source
, 2009 Ribozimi su katalitičke molekule koje moraju biti savijene u visoko uređene tercijarne strukture, kao što to proteini rade da bi obavljali svoje funkcije. Glavni cilj je dovesti nukleofil i izrezujući fosfat u blizinu i aktivirati ih.
Zoko, Nikolina
core +2 more sources
Selection platforms for directed evolution in synthetic biology [PDF]
, 2016 Life on Earth is incredibly diverse. Yet, underneath that diversity, there are a number of constants and highly conserved processes: all life is based on DNA and RNA; the genetic code is universal; biology is limited to a small subset of potential ...
Amstutz +124 more
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Biochemical Characterization of a Lanthanide-Dependent DNAzyme with Normal and Phosphorothioate-Modified Substrates [PDF]
, 2015 This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biochemistry, copyright © American Chemical Society after peer review and technical editing by publisher.
Huang, Po-Jung Jimmy +3 more
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Coordinated control of a designed trans‐acting ligase ribozyme by a loop–receptor interaction
FEBS Letters, 2009 We previously developed a synthetic cis‐acting RNA ligase ribozyme with 3′–5′ joining activity termed “DSL” (designed and selected ligase). DSL was easily transformed into a trans‐acting form because of its highly modular architecture. In this study, we investigated the modular properties and turnover capabilities of a trans‐acting DSL, tDSL‐1/GUAA ...
Matsumura, Shigeyoshi +4 more
openaire +2 more sources
The first peptides: the evolutionary transition between prebiotic amino acids and early proteins [PDF]
, 2009 The issues we attempt to tackle here are what the first peptides did look like when they emerged on the primitive earth, and what simple catalytic activities they fulfilled.
Buhrman, Harry +4 more
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The nonenzymatic template-directed ligation of oligonucleotides
, 2006 International audienceThe nonenzymatic template-directed ligation of oligonucleotides containing 2',3'-cyclic phosphate was investigated in the presence of divalent cations. Ligation of the oligonucleotides readily occurred in the presence of Mg2+, Mn2+,
Chernolovskaya, E. L. +3 more
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Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing [PDF]
, 2011 MicroRNAs (miRNAs) are prevalent regulatory RNAs that mediate gene silencing and play key roles in diverse cellular processes. While synthetic RNA-based regulatory systems that integrate regulatory and sensing functions have been demonstrated, the lack ...
Aagaard +59 more
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How to build a living thing [PDF]
, 2009 Thesis (S.M. in Science Writing)--Massachusetts Institute of Technology, Dept. of Humanities, Graduate Program in Science Writing, 2009.Cataloged from PDF version of thesis.Includes bibliographical references (p.
Campbell, MacGregor (MacGregor Ballard)
core
Local Neutral Networks Help Maintain Inaccurately Replicating Ribozymes [PDF]
, 2014 The error threshold of replication limits the selectively maintainable genome size against recurrent deleterious mutations for most fitness landscapes.
Kun, Ádám +2 more
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