Results 1 to 10 of about 125,351 (338)

The enigma of the RING-UIM E3 ligases: its transformative impact on cancer research [PDF]

Journal of Translational Medicine
RING-UIM E3 ligases, a subfamily within the RING-type E3 ligases, comprise four members: RNF114, RNF125, RNF138, and RNF166. These ligases are crucial in various biological processes, including immunity, inflammation, epigenetics, and homologous ...
Ye Wang, Yue Zhao, Qi Xin, Jihong Zhang
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E3 Ubiquitin Ligases and Their Therapeutic Applications in Cancers: Narrative Review

Journal of Pharmacy and Bioallied Sciences
E3 ubiquitin ligases are a class of enzymes, essential for maintaining the equilibrium of cells by binding ubiquitin molecules to substrates to mark them for destruction.
Azfar Jamal
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E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy [PDF]

MedComm
E3 ubiquitin ligases are pivotal regulators within the ubiquitin–proteasome system, conferring specificity to protein ubiquitination and subsequent degradation, thereby maintaining cellular homeostasis.
Haochen Wang, Junbo Peng, Hongchan Li, Yuzhe Lan, Jing Guo, Qiang Qiu, Xuan Huang   +6 more
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Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment [PDF]

Frontiers in Immunology
Ubiquitination is a modification prevalent in eukaryotic cells. Disruptions in ubiquitination processes can have detrimental effects, potentially leading to diseases that endanger life.
Kun Zhang, Hui Yuan, Lin Shi
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E3 ubiquitin ligases in the acute leukemic signaling pathways

Frontiers in Physiology, 2022
Acute leukemia is a common hematologic tumor with highly genetic heterogeneity, and many factors are involved in the pathogenesis and drug-resistance mechanism.
Qianru Zhan, Heyang Zhang, Boquan Wu, Naijin Zhang, Lijun Zhang   +4 more
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E3 ubiquitin ligases: styles, structures and functions

Molecular Biomedicine, 2021
E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2.
Quan Yang, Jinyao Zhao, Dan Chen, Yang Wang   +3 more
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From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease

Cells, 2022
The ubiquitin–proteasome system is of fundamental importance in all fields of biology due to its impact on proteostasis and in regulating cellular processes.
Valérie C. Cabana, Marc P. Lussier
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The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

Clinical and Translational Medicine, 2023
Ubiquitination is one of the most important post‐translational modifications which plays a significant role in conserving the homeostasis of cellular proteins.
Chibuzo Sampson, Qiuping Wang, Wuxiyar Otkur, Haifeng Zhao, Yun Lu, Xiaolong Liu, Hai‐long Piao   +6 more
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The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer

Cell Death Discovery, 2023
To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve the outcome of CRC patients.
Jie Chen, Haimei Feng, Yiting Wang, Xiaoming Bai, Siqi Sheng, Huiyu Li, Mengxi Huang, Xiaoyuan Chu, Zengjie Lei   +8 more
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The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy

Frontiers in Immunology, 2023
Bladder cancer is one of the common malignant urothelial tumors. Post-translational modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation, have been revealed to participate in bladder cancer initiation and ...
Xuemei Wang, Ying Zhang, Yao Wu, Hongjing Cheng, Xueju Wang   +4 more
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