E3 ubiquitin ligases: styles, structures and functions
E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2.
Yang Wang
exaly +2 more sources
Regulatory Roles of E3 Ubiquitin Ligases and Deubiquitinases in Bone [PDF]
E3 ubiquitin ligases and deubiquitinating enzymes (DUBs) are pivotal regulators of bone homeostasis, orchestrating osteoblast differentiation, proliferation, and osteoclast activity by controlling protein degradation and stability. This review delineates
Haotian He+3 more
doaj +2 more sources
Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA
Protein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses.
Laurent Cappadocia, Ivana Smičiklas
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Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications
Cullin-RING ubiquitin ligases are the largest E3 ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic subunit and ...
Hsin-yi Chen, Ruey-hwa Chen
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Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets
Ubiquitin–proteasome system (UPS) is a primary signaling pathway for regulation of intracellular protein levels. E3 ubiquitin ligases, substrate-specific members of the UPS, represent highly attractive protein targets for drug discovery.
Emil Bulatov+2 more
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E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration
Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of various aberrant proteins in specific brain regions leads to neurodegeneration and aging.
Arun Upadhyay+2 more
exaly +3 more sources
Role and therapeutic potential of E3s in the tumor microenvironment of hepatocellular carcinoma [PDF]
Hepatocellular carcinoma (HCC) is a high-incidence, poor-prognosis malignancy worldwide, requiring new strategies for treatment. Ubiquitination, especially ubiquitination through E3 ubiquitin ligases, plays an indispensable role in the development and ...
Hailin Wang+10 more
doaj +2 more sources
Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA) [PDF]
The development of proteolysis targeting chimeras (PROTACs), which induce the degradation of target proteins by bringing them into proximity with cellular E3 ubiquitin ligases, has revolutionized drug development. While the human genome encodes more than
Bikash Adhikari+4 more
doaj +2 more sources
E3 ubiquitin ligases in the acute leukemic signaling pathways
Acute leukemia is a common hematologic tumor with highly genetic heterogeneity, and many factors are involved in the pathogenesis and drug-resistance mechanism.
Qianru Zhan+4 more
doaj +1 more source
Functional Diversity and Structural Disorder in the Human Ubiquitination Pathway [PDF]
The ubiquitin-proteasome system plays a central role in cellular regulation and protein quality control (PQC). The system is built as a pyramid of increasing complexity, with two E1 (ubiquitin activating), few dozen E2 (ubiquitin conjugating) and several
A Arrigoni+104 more
core +19 more sources