E3 ubiquitin ligases: styles, structures and functions
Molecular Biomedicine, 2021 E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2.
Quan Yang +3 more
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The roles of E3 ubiquitin ligases in cancer progression and targeted therapy
Clinical and Translational Medicine, 2023 Ubiquitination is one of the most important post‐translational modifications which plays a significant role in conserving the homeostasis of cellular proteins.
Chibuzo Sampson +6 more
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The enigma of the RING-UIM E3 ligases: its transformative impact on cancer research [PDF]
Journal of Translational MedicineRING-UIM E3 ligases, a subfamily within the RING-type E3 ligases, comprise four members: RNF114, RNF125, RNF138, and RNF166. These ligases are crucial in various biological processes, including immunity, inflammation, epigenetics, and homologous ...
Ye Wang, Yue Zhao, Qi Xin, Jihong Zhang
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Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment [PDF]
Frontiers in ImmunologyUbiquitination is a modification prevalent in eukaryotic cells. Disruptions in ubiquitination processes can have detrimental effects, potentially leading to diseases that endanger life.
Kun Zhang, Hui Yuan, Lin Shi
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Regulatory Roles of E3 Ubiquitin Ligases and Deubiquitinases in Bone [PDF]
BiomoleculesE3 ubiquitin ligases and deubiquitinating enzymes (DUBs) are pivotal regulators of bone homeostasis, orchestrating osteoblast differentiation, proliferation, and osteoclast activity by controlling protein degradation and stability. This review delineates
Haotian He +3 more
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Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators [PDF]
Advanced ScienceE3 ligases are key regulators of the ubiquitin‐proteasome system (UPS) and have emerged as attractive drug target candidates for precise therapeutic intervention.
Míriam Martínez‐Cartró +13 more
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E3 ubiquitin ligases in the acute leukemic signaling pathways
Frontiers in Physiology, 2022 Acute leukemia is a common hematologic tumor with highly genetic heterogeneity, and many factors are involved in the pathogenesis and drug-resistance mechanism.
Qianru Zhan +4 more
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Cold Spring Harbor Protocols, 2019 DNA ligases are used chiefly to create novel combinations of nucleic acid molecules and to attach them to vectors before molecular cloning. They are either of bacterial origin or bacteriophage encoded and have different properties, as discussed here.
Michael R, Green, Joseph, Sambrook
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From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease
Cells, 2022 The ubiquitin–proteasome system is of fundamental importance in all fields of biology due to its impact on proteostasis and in regulating cellular processes.
Valérie C. Cabana, Marc P. Lussier
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The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer
Cell Death Discovery, 2023 To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve the outcome of CRC patients.
Jie Chen +8 more
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