Transient Induction of Phenylalanine Ammonia-Lyase and 4-Coumarate: CoA Ligase mRNAs in Potato Leaves Infected with Virulent or Avirulent Races of Phytophthora infestans [PDF]
, 1987 Karl‐Heinrich Fritzemeier +6 more
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Advanced Science, EarlyView.Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun +15 more
wiley +1 more source
Temperature Dependence of the Activity of DNA‐Modifying Enzymes: Endonucleases and DNA Ligase [PDF]
, 1982 Fritz M. Pohl, R. Thomae, Antje KARST
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An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy
Advanced Science, EarlyView.This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma +14 more
wiley +1 more source
Kinetic characterization of long chain fatty acyl coenzyme A ligase from rat liver mitochondria.
, 1979 David P. Philipp, Peter G. Parsons
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Primary structures and catalytic properties of isoenzymes encoded by the two 4‐coumarate: CoA ligase genes in parsley [PDF]
, 1988 Edmundo Lozoya‐Gloria +5 more
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Organization of the Proteostasis Network of Membraneless Organelles
Advanced Science, EarlyView.A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim +6 more
wiley +1 more source
Macromolecular crowding allows blunt-end ligation by DNA ligases from rat liver or Escherichia coli. [PDF]
, 1983 Steven B. Zimmerman, Barbara H. Pheiffer
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NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis
Advanced Science, EarlyView.Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong +18 more
wiley +1 more source
DNA ligase and the pyridine nucleotide cycle in Salmonella typhimurium [PDF]
, 1989 U E Park +4 more
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