Results 201 to 210 of about 69,864 (260)

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

A special issue of Essays in Biochemistry on proteasome and protein degradation. [PDF]

Essays Biochem
Sahu I, Glickman MH.
europepmc   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Molecular glue degraders versus PROTACs: a novel paradigm in targeted protein degradation. [PDF]

Ann Med Surg (Lond)
Tahir A, Khan SA, Imtiaz E, Qamar MA.
europepmc   +1 more source

From undruggable to degradable: A deep learning-enabled framework for precision orthopaedic protein degradation. [PDF]

J Orthop Translat
Zhang L, Wang Y, Wang D, Ma J.
europepmc   +1 more source

RBX1⁺ CAFs Drives Pancreatic Ductal Adenocarcinoma Progression Through Tenascin C Overexpression. [PDF]

Cancers (Basel)
Zuo Q, Wang Z, Yang C, Yan B, Li J, Cui M, Cai M, Chen H, Bai X.   +8 more
europepmc   +1 more source

The dual role of the ubiquitin-proteasome system in photomorphogenesis. [PDF]

Essays Biochem
Zhou H, Deng XW.
europepmc   +1 more source

Targeted CENH3 protein depletion in egg cells enables highly efficient haploid induction. [PDF]

Plant Commun
Somasundaram S, Yaşar S, Fuchs J, Cuacos M, Claassen J, Weiss O, Kochevenko A, Lamb JC, Li T, Capdeville N, Puchta H, Houben A.   +11 more
europepmc   +1 more source

E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy. [PDF]

MedComm (2020)
Wang H, Peng J, Li H, Lan Y, Guo J, Qiu Q, Huang X.   +6 more
europepmc   +1 more source

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RNA Ligases

Current Protocols in Molecular Biology, 2008
AbstractT4 RNA ligase 1 catalyzes the ATP‐dependent covalent joining of single‐stranded 5′‐phosphoryl termini of DNA or RNA to single‐stranded 3′‐hydroxyl termini of DNA or RNA. T4 RNA ligase 2 also catalyzes the joining of a 3′‐hydroxyl terminus of RNA to a 5′‐phosphorylated RNA or DNA; unlike T4 RNA ligase 1, this enzyme prefers double‐stranded ...
Nicole M, Nichols, Stanley, Tabor, Larry A, McReynolds   +2 more
openaire   +2 more sources