Results 221 to 230 of about 83,359 (255)

Ubiquitin E3 ligase activity in TRIpartite Motif (TRIM) family proteins. [PDF]

Biochem Soc Trans
Dudley-Fraser J, Rittinger K.
europepmc   +1 more source

MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation

Advanced Science, EarlyView.
We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui, Lin Mao, Binggang Li, Hanyue Kang, Zhengquan Tang, Sheng Chen, Hui Yang, Yu Qiao, Huiqian Ding, Yuhuan Wang, Min Li, Junjie Hu, Shoudong Ye, Xin Wang, Xiaobin Xu, Yupeng Wang, Tana Wuren, Qian Ban, Baowei Zhang   +18 more
wiley   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Proteostasis and ageing dissidence. [PDF]

Philos Trans R Soc Lond B Biol Sci
Babu N, Whalen K, Freeman B.
europepmc   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Catalytic loop closure governs substrate selectivity in the rhizocticin biosynthetic ligases RhiM and RhiC. [PDF]

J Biol Chem
Sakai M, Masuda R, Hirano Y, Tamada T, Nakamura A.   +4 more
europepmc   +1 more source

A mitochondria-driven quality control mechanism for peroxisomal membrane proteins. [PDF]

Nat Commun
Segev-Nakar S, Koren I.
europepmc   +1 more source

The Ubiquitin-Proteasome System in Flowering Plant Reproduction: Mechanisms, Functional Diversity, and Regulatory Networks. [PDF]

Plants (Basel)
Jiang X, Su H, Chai M, Yang F, Cai H, Qin Y, Yan M.   +6 more
europepmc   +1 more source

Mechanisms and strategies of host xenophagy manipulation by intracellular bacteria. [PDF]

Cell Mol Life Sci
Song Y, Tang L, Li N, Zhou X, Chu Y.
europepmc   +1 more source

Selective and Efficient Functionalization of P22 Virus-Like Particles Using an Asparaginyl Ligase. [PDF]

Bioconjug Chem
Harding MD, Jackson MA, Yap K, Huda P, Craik DJ, Sainsbury F, Lawrence N.   +6 more
europepmc   +1 more source